Home > Name List By other > (3R, 4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4- hydroxyphenyl)azetidin-2-one

CAS No 163222-33-1 , (3R,
4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-
hydroxyphenyl)azetidin-2-one

  • Name: (3R,
    4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-
    hydroxyphenyl)azetidin-2-one
  • Synonyms: (3R,
    4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-
    hydroxyphenyl)azetidin-2-one; 163222-33-1; Ezetrol;Zetia; SCH-58235; Zient; S1655_Selleck; Sch 58235; Ezedoc; Zetia (TN);
  • CAS Registry Number:
  • Flash Point: 349.9°C
  • Boiling Point: 654.9°C at 760 mmHg
  • Density: 1.334g/cm3
  • Refractive index: 1.623
  • Safety Statements: R36/37/38,
  • Flash Point: 349.9°C
  • Molecular Weight: 409.425246
  • InchiKey: OLNTVTPDXPETLC-XPWALMASSA-N
  • InChI: InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20
    (28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,
    13-14H2/t21-,22+,23-/m1/s1
  • Risk Statements: S26-36,
  • Molecular Formula: C24H21F2NO3
  • Molecular Structure:CAS No:163222-33-1 (3R,<br />4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-<br />hydroxyphenyl)azetidin-2-one
Search by region :

Select to

163222-33-1 Ezetimibe

  • China Arylchem [Manufacturer]
  • Tel: +86-536-5217866/ +86-133-863-67823
  • Fax: +86-536-5225653
  • Address: No.75 Yinhai Road, Shouguang, Shandong Province,
    China 262700 null,nullChina
Contact Supplier

163222-33-1 Ezetimibe

  • India Exim-Pharm International null
  • Tel: +91-(22)-26191948
  • Fax: +91-(22)-26191948
  • Address: 1, Ashish Mahal, 2nd Floor, Ist Road, Golibar Santacruz (E), Mumbai, Maharashtra 400 055, null,nullIndia
Contact Supplier

163222-33-1 Ezetimibe

  • China Hwasun Biotechnology Co., Ltd. null
  • Fax: 86-21-64765024
  • Address: Rm.505, Bldg. 2,No. 245 Jiachuan RD. Xuhui Dist.,200237, Shanghai, China null,nullChina
Contact Supplier

163222-33-1 Ezetimibe

Contact Supplier

163222-33-1 Ezetimibe

  • China IFFECT CHEMPHAR CO., LTD. null
  • Tel: 0086 755-83761619 83760606
  • Fax: +86-25- 84270111
  • Address: 15A,Changfa Center, Building B ,No. 300,East Zhongshan Road,Baixia District,Nanjing,210002, P.R.China. Nanjing,JiangshuChina
Contact Supplier

163222-33-1 Ezetimibe

Contact Supplier

163222-33-1 Ezetimibe

Contact Supplier

163222-33-1 EZETIMIBE

  • United States SST Corporation [Manufacturer]
  • Tel: 800-222-0921/ 973-473-4300
  • Fax: 973-473-4326
  • Address: SST Corporation
    635 Brighton Road
    Clifton, NJ 07012 null,nullUnited States
Contact Supplier

163222-33-1 EZETIMIBE

Contact Supplier

163222-33-1 Ezetimibe

Contact Supplier

Select to

References of (3R,
4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-
hydroxyphenyl)azetidin-2-one
Title: Ezetimibe
CAS Registry Number: 163222-33-1
CAS Name: (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
Manufacturers' Codes: Sch-58235
Trademarks: Ezetrol (Merck/Schering-Plough); Zetia (Merck/Schering-Plough)
Molecular Formula: C24H21F2NO3
Molecular Weight: 409.43
Percent Composition: C 70.40%, H 5.17%, F 9.28%, N 3.42%, O 11.72%
Literature References: Cholesterol absorption inhibitor. Prepn: S. B. Rosenblum et al., WO 9508532; eidem, US 5767115 (1995, 1998 both to Schering); idem et al., J. Med. Chem. 41, 973 (1998). Enantioselective synthesis: G. Wu et al., J. Org. Chem. 64, 3714 (1999). Activity in animals: M. van Heek et al., J. Pharmacol. Exp. Ther. 283, 157 (1997). Metabolism and distribution: eidem, Br. J. Pharmacol. 129, 1748 (2000). Review of pharmacology and clinical studies: H. Bays, Expert Opin. Invest. Drugs 11, 1587-1604 (2002).
Properties: White solid, mp 164-166°. [a]D22 -33.9° (c = 3 in methanol).
Melting point: mp 164-166°
Optical Rotation: [a]D22 -33.9° (c = 3 in methanol)
Therap-Cat: Antilipemic.
Keywords: Antilipemic.