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CAS No 164656-23-9 , Dutasteride Search by region : Macao

  • Name: Dutasteride
  • Synonyms: Dutasteride;(5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;
  • CAS Registry Number:
  • Density: 1.303 g/cm3
  • Refractive index: 1.523
  • Molecular Weight: 528.53
  • InChI: InChI=1/C27H30F6N2O2/c1-24-11-9-17-15(4-8-21-25(17,2)12-10-22(36)35-21)16(24)6-7-19(24)23(37)34-20-13-14(26(28,29)30)3-5-18(20)27(31,32)33/h3,5,10,12-13,15-17,19,21H,4,6-9,11H2,1-2H3,(H,34,37)(H,35,36)/t15-,16-,17?,19+,21+,24-,25+/m0/s1
  • Molecular Formula: C27H30F6N2O2
  • Molecular Structure:CAS No:164656-23-9 Dutasteride

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References of Dutasteride
Title: Dutasteride
CAS Registry Number: 164656-23-9
CAS Name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-[2,5-Bis(trifluoromethyl)phenyl]-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide
Synonyms: 17b-N-[2,5-Bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5a-androst-1-en-3-one
Manufacturers' Codes: GG-745; GI-198745
Trademarks: Avodart (GSK); Avolve (GSK)
Molecular Formula: C27H30F6N2O2
Molecular Weight: 528.53
Percent Composition: C 61.36%, H 5.72%, F 21.57%, N 5.30%, O 6.05%
Literature References: Dual inhibitor of 5a-reductase isoenzymes types 1 and 2; structurally related to finasteride, q.v. Prepn: K. W. Batchelor, S. V. Frye, WO 9507927 (1995 to Glaxo). Structure-activity study: R. K. Bakshi et al., J. Med. Chem. 38, 3189 (1995). Clinical pharmacokinetics: P. O. Gisleskog et al., Br. J. Clin. Pharmacol. 47, 53 (1999). Clinical trial in benign prostatic hyperplasia: C. G. Roehrborn et al., Urology 60, 434 (2002). Review of discovery and development: S. V. Frye et al., Pharm. Biotechnol. 11, 393-422 (1998); of clinical experience: B. Djavan et al., Expert Opin. Pharmacother. 6, 311-317 (2005).
Properties: White crystalline solid, mp 245-245.5°.
Melting point: mp 245-245.5°
Therap-Cat: In treatment of benign prostatic hyperplasia.
Keywords: 5a-Reductase Inhibitor; Antiprostatic Hypertrophy.