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CAS No 1668-19-5 , 1-Propanamine,3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl- Search by region : India

  • Name: 1-Propanamine,3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-
  • Synonyms: Dibenz[b,e]oxepin, 1-propanamine deriv.;11-[3-(Dimethylamino)propylidene]-6H-dibenz[b,e]oxepin; Doxepine;N,N-Dimethyldibenz[b,e]oxepin-D11(6H),g-propylamine;NSC 108160;Dibenz[b,e]oxepin-D11(6H),g-propylamine, N,N-dimethyl-(7CI,8CI); Doxepin;1-Propanamine,3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-;
  • CAS Registry Number:
  • Density: 1.122 g/cm3
  • Water Solubility: readily soluble in water, lower
  • Safety Statements: Human poison by ingestion. Experimental poison by ingestion, intravenous, and intraperitoneal routes. A sedative and hypnotic used as an antianxiety agent. When heated to decomposition it emits toxic fumes of NOx.
  • Molecular Weight: 279.41
  • InChI: InChI=1/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/p+1/b17-11-
  • Molecular Formula: C19H21 N O
  • Molecular Structure:CAS No:1668-19-5 1-Propanamine,3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-

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1668-19-5 doxepin

  • IUPAC NAME-(E/Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine MOLECULAR FORMULA-C19H21NO MOLAR MASS-279.376 g/mol Doxepin is a psychotropic agent with tricyclic antidepressant and anxiolytic properties,
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References of 1-Propanamine,3-dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-
Title: Doxepin
CAS Registry Number: 1668-19-5
CAS Name: 3-Dibenz[b,e]oxepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine
Synonyms: N,N-dimethyldibenz[b,e]oxepin-D11(6H),g-propylamine; 11-(3-dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepin
Manufacturers' Codes: P-3693A
Molecular Formula: C19H21NO
Molecular Weight: 279.38
Percent Composition: C 81.68%, H 7.58%, N 5.01%, O 5.73%
Literature References: Prepn of mixture of cis- and trans-isomers: K. Stach, F. Bickelhaupt, Monatsh. Chem. 93, 896 (1962); F. Bickelhaupt et al., ibid. 95, 485 (1964); NL 6407758; K. Stach, US 3438981 (1965, 1969 both to Boehringer Mann.); and separation and activity of isomers: B. M. Bloom, J. R. Tretter, BE 641498; eidem, US 3420851 (1964, 1969 both to Pfizer). Pharmacology: A. Ribbentrop, W. Schaumann, Arzneim.-Forsch. 15, 863 (1965). Metabolism in animals: D. C. Hobbs, Biochem. Pharmacol. 18, 1941 (1969). Determn in plasma by GC/MS: T. P. Davis et al., J. Chromatogr. 273, 436 (1983); by HPLC: T. Emm, L. J. Lesko, ibid. 419, 445 (1987). Clinical study in depression: K. Rickels et al., Arch. Gen. Psychiatry 42, 134 (1985). Comparative clinical trial with cimetidine, q.v., in treatment of ulcer: R. K. Shrivastava et al., Clin. Ther. 7, 181 (1985). Review of pharmacology and therapeutic efficacy: R. M. Pinder et al., Drugs 13, 161 (1977).
Properties: Oily liq consisting of a mixture of cis- and trans-isomers. bp0.03 154-157°, bp0.2 260-270°. LD50 in mice, rats (mg/kg): 26, 16 i.v.; 79, 182 i.p.; 135, 147 orally (Ribbentrop, Schaumann).
Boiling point: bp0.03 154-157°; bp0.2 260-270°
Toxicity data: LD50 in mice, rats (mg/kg): 26, 16 i.v.; 79, 182 i.p.; 135, 147 orally (Ribbentrop, Schaumann)
 
Derivative Type: Hydrochloride
CAS Registry Number: 1229-29-4
Trademarks: Adapin (Lotus); Aponal (Boehringer, Mann.); Curatin (Pfizer); Quitaxon (Boehringer, Mann.); Sinequan (Pfizer)
Molecular Formula: C19H21NO.HCl
Molecular Weight: 315.84
Percent Composition: C 72.25%, H 7.02%, N 4.43%, O 5.07%, Cl 11.22%
Properties: Crystals, mp 184-186°, 188-189°.
Melting point: mp 184-186°, 188-189°
 
Derivative Type: Maleate
Properties: Crystals, mp 161-164°, 168-169°.
Melting point: mp 161-164°, 168-169°
 
Derivative Type: trans-Form hydrochloride
CAS Registry Number: 3607-18-9
Properties: mp 192-193°.
Melting point: mp 192-193°
 
Derivative Type: cis-Form hydrochloride
CAS Registry Number: 25127-31-5
Synonyms: Cidoxepin hydrochloride
Manufacturers' Codes: P-4599
Properties: Crystals, mp 209-210.5°.
Melting point: mp 209-210.5°
 
Therap-Cat: Antidepressant.
Therap-Cat-Vet: Antipruritic.
Keywords: Antidepressant; Tricyclics.