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CAS No 1695-77-8 , Spectinomycin Search by region : China

  • Name: Spectinomycin
  • Synonyms: Antibiotic 2233wp; Spectinomicina [Italian];actinospectacin; Espectinomicina;Spectinomycin; Spectam; Togamycin; Actinospectacina [Italian]; Trobicin;
  • CAS Registry Number:
  • Density: 1.43 g/cm3
  • EINECS: 216-911-3
  • Molecular Weight: 332.34956
  • InchiKey: UNFWWIHTNXNPBV-WXKVUWSESA-N
  • InChI: InChI=1S/C14H24N2O7/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8
    (16-3)11(12)23-14/h5,7-13,15-16,18-20H,4H2,1-3H3/t5-,7-,8+,9+,10+,11-,
    12-,13+,14+/m1/s1
  • Molecular Formula: C14H24N2O7
  • Molecular Structure:CAS No:1695-77-8 Spectinomycin

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1695-77-8 spectinomycin

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1695-77-8 spectinomycin

  • China ORCHID CHEMICAL SUPPLIES LTD (OCS) [Importer/Exporter]
  • Tel: +86-571-85395792
  • Fax: +86-571-85420103
  • Address: 607, North Zhongshan Road, Hangzhou 310000 China null,ZhejiangChina
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1695-77-8 Spectinomycin HCl/Sulphate

  • China Xingcheng Chempharm Co., Ltd [Manufacturer]
  • Tel: +86-576-88525005/ +86-576-88886292
  • Fax: +86-576-88225056
  • Address: B Area, 10F, Yaoda Mansion, 289, Shifu Road, Taizhou, Zhejiang, China 318000 null,nullChina
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1695-77-8 spectinomycin

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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1695-77-8 Spectinomycin

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1695-77-8 SPECTINOMYCIN

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA null,nullChina
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1695-77-8 Spectinomycin HCl/Sulphate

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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1695-77-8 spectinomycin

  • China VETCHEM Biochemistry Science [Manufacturer, Distributor/Wholesaler]
  • Tel: +86-21-593837
  • Address: No.2 Jinshanwei Industrial Zon,Shanghai 200120 China Shanghai,ShanghaiChina
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1695-77-8 Spectinomycin

  • China Chemfar Ltd. null
  • Fax: 86-571-87859289
  • Address: 16E,Huarong Times Mansion, No.3880 Jiangnan Avenue, Binjiang District, Hangzhou, China null,nullChina
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1695-77-8 spectinomycin

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References of Spectinomycin
Title: Spectinomycin
CAS Registry Number: 1695-77-8
CAS Name: [2R-(2a,4ab,5ab,6b,7b,8b,9a,9aa,10ab)]-Decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-4H-pyrano[2,3-b][1,4]benzodioxin-4-one
Synonyms: actinospectacin; espectinomicina
Manufacturers' Codes: CHX-3101; M-141
Molecular Formula: C14H24N2O7
Molecular Weight: 332.35
Percent Composition: C 50.59%, H 7.28%, N 8.43%, O 33.70%
Literature References: Antibiotic isolated from fermentation broth of Streptomyces spectabilis: D. J. Mason et al., Antibiot. Chemother. 11, 118 (1961); M. E. Bergy et al., ibid. 661; M. E. Bergy, C. De Boer, US 3234092 (1966 to Upjohn). Purification and crystallization: H. K. Jahnke, US 3206360; V. J. Peters, US 3272706 (1965, 1966 both to Upjohn). Isoln and characterization: A. C. Sinclair, A. F. Winfield, Antimicrob. Agents Chemother. 1961, 503. Structure: H. Hoeksema et al., J. Am. Chem. Soc. 84, 3212 (1962); P. F. Wiley et al., ibid. 85, 2652 (1963). Solubility data: J. R. Marsh, P. J. Weiss, J. Assoc. Off. Anal. Chem. 50, 457 (1967). Stereochemistry and abs config: T. G. Cochran et al., Chem. Commun. 1972, 494. Biosynthesis: L. A. Mitscher et al., ibid. 1971, 1541; H. Otsuka et al., J. Am. Chem. Soc. 102, 6817 (1980). Enantioselective synthesis: D. R. White et al., Tetrahedron Lett. 1979, 2737; S. Hanessian, R. Roy, Can. J. Chem. 63, 163 (1985). Mechanism of action study: M. F. Brink et al., Nucleic Acids Res. 22, 325 (1994). HPLC determn in animal plasma: N. Haagsma et al., J. Chromatogr. 615, 289 (1993). Clinical pharmacokinetics: J. G. Wagner et al., Int. Z. Klin. Pharmakol. Ther. Toxikol. 1, 261 (1968). Clinical evaluation in gonorrhea: Y. H. Kouri et al., Genitourin. Med. 65, 342 (1989); in chancroid: M. Guzmán et al., Sex. Transm. Dis. 19, 291 (1992). Co-treatment with lincomycin, q.v., for footrot in sheep: C. M. Venning et al., Aust. Vet. J. 67, 258 (1990). Reviews: W. M. McCormack, M. Finland, Ann. Intern. Med. 84, 712-716 (1976); W. J. Holloway, Med. Clin. North Am. 66, 169-173 (1982).
Properties: Amorphous powder. [a]D25 -20° (water). pKa¢1 6.95, pKa¢2 8.70. Sol in water, methanol, ethanol. Insol in acetone, hydrocarbon solvents.
pKa: pKa¢1 6.95, pKa¢2 8.70
Optical Rotation: [a]D25 -20° (water)
 
Derivative Type: Dihydrochloride pentahydrate
CAS Registry Number: 22189-32-8
Trademarks: Spectam (Abbott); Stanilo (Pharmacia); Trobicin (Pharmacia & Upjohn)
Molecular Formula: C14H24N2O7.2HCl.5H2O
Molecular Weight: 495.35
Percent Composition: C 33.95%, H 7.33%, N 5.66%, O 38.76%, Cl 14.31%
Literature References: Exists as a ketone hydrate and not in the carbonyl form (Cochran et al.).
Properties: Colorless needles from aq acetone, mp 205-207° (dec). [a]D +14.8° (c = 0.42 in water). Soly in water, methanol, propylene glycol, formamide, DMSO, 0.1N NaOH, 0.1N HCl: >20 mg/ml. Soly (mg/ml): chloroform 0.042; acetone 0.015; diethyl ether 0.010.
Melting point: mp 205-207° (dec)
Optical Rotation: [a]D +14.8° (c = 0.42 in water)
 
Derivative Type: Sulfate tetrahydrate
CAS Registry Number: 64058-48-6
Molecular Formula: C14H24N2O7.H2SO4.4H2O
Molecular Weight: 502.49
Percent Composition: C 33.46%, H 6.82%, N 5.57%, O 47.76%, S 6.38%
Properties: White crystals from aq acetone, mp ~185° (dec). [a]D25 +17.0° (c = 1 in water). pKa¢1 7.00, pKa¢2 8.75. Soly in water, DMSO: 225, 5-10 (mg/ml). Practically insol in pyridine, chloroform, ethanol, ethyl acetate, cyclohexane, benzene, acetone, DMF, dioxane, acetonitrile.
Melting point: mp ~185° (dec)
pKa: pKa¢1 7.00, pKa¢2 8.75
Optical Rotation: [a]D25 +17.0° (c = 1 in water)
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.