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CAS No 169590-42-5 , 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide Search by region : Canada

  • Name: 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
  • Synonyms: Celecoxi; Onsenal;Celebrex; Celocoxib; Celebra;4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide; SC 58635; Xilebao; Celecox; 169590-42-5;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 157-159 ºC
  • Boiling Point:
  • Density: 1.43 g/cm3
  • Water Solubility: Insoluble
  • Safety Statements: S22;S24/25;S28;S37/39;
  • Hazard Symbols: UN NO.
  • Molecular Weight: 381.37217
  • InchiKey: RZEKVGVHFLEQIL-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,
    19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
  • Risk Statements: R20/21/22
  • Molecular Formula: C17H14F3N3O2S
  • Molecular Structure:CAS No:169590-42-5 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide

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169590-42-5 Celecoxib

  • Canada Dalton Pharma Services [Manufacturer]
  • Tel: (416)-661-2102/ (800)-567-5060 (Canada Only)
  • Fax: 416-661-2108
  • Address: Dalton Pharma Services
    349 Wildcat Rd.
    Toronto, ON
    M3J 2S3
    CANADA null,nullCanada
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169590-42-5 CELECOXIB

  • Canada SynFine Research Inc. [Manufacturer]
  • Tel: 905-737-2702
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  • Address: SynFine Research Inc.
    P.O. Box 433 ? Station A
    Richmond Hill, ON L4C 4Y8
    Canada null,nullCanada
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169590-42-5 Celebrex

  • CelebrexCelecoxib, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide
  • Canada Toronto Research Chemicals [Manufacturers]
  • Tel: (416) 665-9696, 800-727-9240
  • Fax: 416 665-4439
  • Address: 2 Brisbane Rd.,North York, On.Canada M3J 2J8 null,nullCanada
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169590-42-5 CELECOXIB-D7

  • Canada TLC PharmaChem., Inc. [Manufacturer]
  • Tel: 905-760-1098
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  • Address: TLC PharmaChem., Inc.
    5-150 Connie Crescent
    Concord, Ontario
    L4K 1L9, Canada null,nullCanada
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169590-42-5 CELECOXIB

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
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  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
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    H4P 2R2 null,nullCanada
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References of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
Title: Celecoxib
CAS Registry Number: 169590-42-5
CAS Name: 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide
Manufacturers' Codes: SC-58635; YM-177
Trademarks: Celebrex (Pfizer); Onsenal (Pfizer)
Molecular Formula: C17H14F3N3O2S
Molecular Weight: 381.37
Percent Composition: C 53.54%, H 3.70%, F 14.94%, N 11.02%, O 8.39%, S 8.41%
Literature References: Selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: J. J. Talley et al., WO 9515316; eidem, US 5466823 (both 1995 to Searle); T. D. Penning et al., J. Med. Chem. 40, 1347 (1997). Clinical pharmacology: P. E. Lipsky, P. C. Isakson, J. Rheumatol. 24, Suppl. 49, 9 (1997). Clinical trials in arthritis: L. S. Simon et al., Arthritis Rheum. 41, 1591 (1998). Evaluation of risk of gastrointestinal toxicity in patients with arthritis: F. E. Silverstein et al., J. Am. Med. Assoc. 284, 1247 (2000). Clinical trial in familial adenomatous polyposis: G. Steinbach et al., N. Engl. J. Med. 342, 1946 (2000).
Properties: Pale yellow solid, mp 157-159°.
Melting point: mp 157-159°
Therap-Cat: Anti-inflammatory. In treatment of familial adenomatous polyposis.
Keywords: Anti-inflammatory (Nonsteroidal); Cyclooxygenase-2 Selective Inhibitor.