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CAS No 169939-94-0 , Ruboxistaurin Search by region : Canada

  • Name: Ruboxistaurin
  • Synonyms: UNII-721809WQCP; AC1L4BIF; LY 333531; CHEMBL91829; Ruboxistaurin [INN]; K00587a;Ruboxistaurin;LY-333531; 1uu3;
  • CAS Registry Number:
  • Flash Point: 404°C
  • Boiling Point: 744.4°Cat760mmHg
  • Density: 1.34
  • Refractive index: 1.695
  • Flash Point: 404°C
  • Molecular Weight: 468.54692
  • InchiKey: ZCBUQCWBWNUWSU-SFHVURJKSA-N
  • InChI: InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-
    26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,
    16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1
  • Molecular Formula: C28H28N4O3
  • Molecular Structure:CAS No:169939-94-0 Ruboxistaurin

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169939-94-0 RUBOXISTAURIN MESYLATE MONOHYDRATE

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
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References of Ruboxistaurin
Title: Ruboxistaurin
CAS Registry Number: 169939-94-0
CAS Name: (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione
Synonyms: (S)-3,4-[(N,N￠-1,1￠-((2￠￠-ethoxy)-3￠￠￠(O)-4￠￠￠-(N,N-dimethylamino)butane)-bis-(3,3￠-indolyl))]-1(H)-pyrrole-2,3-dione
Manufacturers' Codes: LY-333531
Molecular Formula: C28H28N4O3
Molecular Weight: 468.55
Percent Composition: C 71.77%, H 6.02%, N 11.96%, O 10.24%
Literature References: Protein kinase Cb (PKCb) inhibitor; macrocyclic bisindolylmaleimide. Prepn: W. F. Heath, Jr. et al., EP 657458; eidem, US 5552396 (1995, 1996 both to Eli Lilly); M. R. Jirousek et al., J. Med. Chem. 39, 2664 (1996); M. M. Faul et al., J. Org. Chem. 63, 1961 (1998). Characterization of salt forms: G. L. Engel et al., Int. J. Pharm. 198, 239 (2000). Enantioselective synthesis: B. M. Trost, W. Tang, Org. Lett. 3, 3409 (2001). Antiangiogenic activity: R. P. Danis et al., Invest. Ophthalmol. Visual Sci. 39, 171 (1998). Clinical trial in diabetic retinopathy: PKC-DRS Study Group, Diabetes 54, 2188 (2005); in diabetic neuropathy: A. I. Vinik et al., Clin. Ther. 27, 1164 (2005); in diabetic nephropathy: K. R. Tuttle et al., Diabetes Care 28, 2686 (2005). Review of pharmacology and therapeutic potential: S. V. Joy et al., Ann. Pharmacother. 39, 1693-1699 (2005); A. Vinik, Expert Opin. Invest. Drugs 14, 1547-1559 (2005).
Properties: uv max (ethanol): 493, 382, 282, 232, 204 nm (e 3944, 3796, 9946, 38382, 43887). Soly in water: <1 mg/ml.
Absorption maximum: uv max (ethanol): 493, 382, 282, 232, 204 nm (e 3944, 3796, 9946, 38382, 43887)
 
Derivative Type: Hydrochloride
CAS Registry Number: 169939-93-9
Molecular Formula: C28H28N4O3.HCl
Molecular Weight: 505.01
Percent Composition: C 66.59%, H 5.79%, N 11.09%, O 9.50%, Cl 7.02%
Properties: Orange cake. [a]D25 -28.7° (c = 1.0 in ethanol). Soly in water: 0.1 mg/ml.
Optical Rotation: [a]D25 -28.7° (c = 1.0 in ethanol)
 
Derivative Type: Methanesulfonate monohydrate
CAS Registry Number: 202260-21-7; 192050-59-2 (anhydrous)
Synonyms: Ruboxistaurin mesylate monohydrate
Trademarks: Arxxant (Lilly)
Molecular Formula: C28H28N4O3.CH4O3S.H2O
Molecular Weight: 582.67
Percent Composition: C 59.78%, H 5.88%, N 9.62%, O 19.22%, S 5.50%
Properties: Thin red or red-orange plates from acetone/water. Dec 270°. Soly in water: 0.5 mg/ml.
 
Therap-Cat: In treatment of diabetic microvascular complications.