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CAS No 1744-22-5 , 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine Search by region : Germany

  • Name: 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
  • Synonyms: Riluzole HCl; 1744-22-5; 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine;6-(trifluoromethoxy)-1,3-benzothiazol-2-amine; RP-54274; 2-Amino-6-(trifluoromethoxy)benzothiazole;Rilutek;
  • CAS Registry Number:
  • Transport: UN 2811
  • Flash Point: 133 ºC
  • Boiling Point: 296.3 ºC at 760 mmHg
  • Density: 1.572 g/cm3
  • Safety Statements: R25
  • Hazard Symbols: T: Toxic;
  • Flash Point: 133 ºC
  • Molecular Weight: 234.19831
  • InchiKey: FTALBRSUTCGOEG-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,
    12,13)
  • Risk Statements: S45
  • Molecular Formula: C8H5F3N2OS
  • Molecular Structure:CAS No:1744-22-5 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

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References of 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine
Title: Riluzole
CAS Registry Number: 1744-22-5
CAS Name: 6-(Trifluoromethoxy)-2-benzothiazolamine
Synonyms: 2-amino-6-(trifluoromethoxy)benzothiazole
Manufacturers' Codes: PK-26124; RP-54274
Trademarks: Rilutek (Aventis)
Molecular Formula: C8H5F3N2OS
Molecular Weight: 234.20
Percent Composition: C 41.03%, H 2.15%, F 24.34%, N 11.96%, O 6.83%, S 13.69%
Literature References: Modulates glutamatergic transmission. Prepn: L. M. Yagupol'skii, L. Z. Gandel'sman, Zh. Obshch. Khim. 33, 2301 (1963), C.A. 60, 692a (1964). Prepd but not claimed: J. Mizoule, EP 50551; idem, US 4370338 (1982, 1983 both to Pharmindustrie). Pharmacology: J. Mizoule et al., Neuropharmacology 24, 767 (1985); F. Wahl et al., Eur. J. Pharmacol. 230, 209 (1993). Mechanism of action studies: M.-W. Debono et al., ibid. 235, 283; D. Martin et al., ibid. 250, 473. Use in treatment of motor nerve diseases: E. Louvel, EP 558861 (1993 to Rh?ne-Poulenc Rorer). Clinical study in amyotrophic lateral sclerosis: G. Bensimon et al., N. Engl. J. Med. 330, 585 (1994). Review: J. Wokke, Lancet 348, 795-799 (1996).
Properties: Crystals from ethanol/water (1:1), mp 119°. LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule).
Melting point: mp 119°
Toxicity data: LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule)
Therap-Cat: Neuroprotective.
Keywords: Neuroprotective.