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CAS No 17902-23-7 , Tegafur

  • Name: Tegafur
  • Synonyms: Tegafur; Epsilone Acid; 1-Naphthol-3,8-Disulfonic Acid;5-Fluoro-1-(tetrahydro-2-furyl)uracil;Tegafur; 5-fluoro-1-oxolan-2-yl-pyrimidine-2,4-dione; 5-fluoro-1-(tetrahydrofuran-2-yl)uracil; 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione; 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 168-171 ºC
  • Flash Point: ºC
  • Boiling Point: ºCat760mmHg
  • Density: 1.45 g/cm3
  • Refractive index: 1.557
  • Water Solubility: Soluble in hot water
  • Safety Statements: R23/24/25
  • Hazard Symbols: T: Toxic;
  • Flash Point: ºC
  • EINECS: 241-846-2
  • Molecular Weight: 200.17
  • InChI: InChI=1/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
  • Risk Statements: S22;S36/37/39;S45
  • Molecular Formula: C8H9FN2O3
  • Molecular Structure:CAS No:17902-23-7 Tegafur

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References of Tegafur
Title: Tegafur
CAS Registry Number: 17902-23-7
CAS Name: 5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione
Synonyms: 5-fluoro-1-(tetrahydro-2-furyl)uracil; N1-(2￠-furanidyl)-5-fluorouracil
Manufacturers' Codes: FT-207; MJF-12264; NSC-148958
Trademarks: Citofur (Lusofarmaco); Coparogin (Nippon Chemiphar); Exonal (Toyama); Fental (Kanebo); Franrose (Hishiyama); Ftorafur (Grñenthal); Fulaid (Takeda); Fulfeel (Kyorin); Furafluor (Green Cross); Furofutran (Taiyo); Futraful (Taiho); Lamar (Tokyo Tanabe); Lifril (Kissei); Neberk (Morishita); Nitobanil (Kyowa Yakuhin); Riol (Toa Eiyo); Sinoflurol (Kaken); Sunfural (Asahi Kasei); Tefsiel C (Towa Yakuhin)
Molecular Formula: C8H9FN2O3
Molecular Weight: 200.17
Percent Composition: C 48.00%, H 4.53%, F 9.49%, N 13.99%, O 23.98%
Literature References: Prepn: S. A. Hillers et al., Dokl. Akad. Nauk SSSR 176, 332 (1967), C.A. 68, 29664j (1968); eidem, GB 1168391 (1969), C.A. 72, 43715r (1970) and FR 1574684 (1969), C.A. 73, 77281g (1970). Alternate synthesis: T. Kametani et al., J. Heterocycl. Chem. 14, 473 (1977). Synthesis, antitumor activity, toxicity study: M. Yasumoto et al., J. Med. Chem. 21, 738 (1978). Crystal structure: Y. Nakai, Chem. Pharm. Bull. 30, 2629 (1982). Pharmacokinetics, metabolism in man: J. L. Au et al., Cancer Treat. Rep. 63, 343 (1979). Evaluation of efficacy and toxicity: C. R. Smart et al., Cancer 36, 103 (1975). Evaluation in colorectal cancer: T. Buroker et al., Cancer 44, 48 (1979). In vivo and in vitro studies on Walker carcinoma in rats: J. Mattern et al., Arzneim.-Forsch. 30, 981 (1980).
Properties: Crystals from ethanol, mp 164-165°. uv max: 270 nm [e 8460 (pH 2); e 8050 (pH 7); e 6700 (pH 12)]. Easily sol in hot water, alcohol, DMF. Practically insol in ether. LD50 in mice (mg/kg): 900 orally (3 days) (Yasumoto); 750 i.p. (FR 1574684), also reported as 1150 i.p. (Smart).
Melting point: mp 164-165°
Absorption maximum: uv max: 270 nm [e 8460 (pH 2); e 8050 (pH 7); e 6700 (pH 12)]
Toxicity data: LD50 in mice (mg/kg): 900 orally (3 days) (Yasumoto); 750 i.p. (FR 1574684), also reported as 1150 i.p. (Smart)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Pyrimidine Analogs.