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CAS No 181695-72-7 , 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide

  • Name: 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
  • Synonyms: 4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide; Kudeq;Bextra; SC-65872; SC 65872; Valdyn;4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide; 181695-72-7;
  • CAS Registry Number:
  • Density: 1.303 g/cm3
  • Refractive index: 1.608
  • Molecular Weight: 314.35896
  • InchiKey: LNPDTQAFDNKSHK-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,
    19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20)
  • Molecular Formula: C16H14N2O3S
  • Molecular Structure:CAS No:181695-72-7 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide

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References of 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
Title: Valdecoxib
CAS Registry Number: 181695-72-7
CAS Name: 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
Manufacturers' Codes: SC-65872
Trademarks: Bextra (Pharmacia & Upjohn)
Molecular Formula: C16H14N2O3S
Molecular Weight: 314.36
Percent Composition: C 61.13%, H 4.49%, N 8.91%, O 15.27%, S 10.20%
Literature References: Selective cyclooxygenase-2 (COX-2) inhibitor. Active metabolite of parecoxib, q.v. Prepn: J. J. Talley et al., WO 9625405 (1996 to Searle); eidem, US 5633272 (1997); and activity: eidem, J. Med. Chem. 43, 775 (2000). Chromatographic determn of purity: D. A. Roston et al., J. Pharm. Biomed. Anal. 26, 339 (2001). Gastrointestinal tolerability study: G. M. Eisen et al., Aliment. Pharmacol. Ther. 21, 591 (2005). Clinical trial in hip arthroplasty: F. Camu et al., Am. J. Ther. 9, 43 (2002). Clinical comparison with oxycodone/acetominophen in dental pain: S. E. Daniels et al., J. Am. Dent. Assoc. 133, 611 (2002). Clinical trial in migraine: D. Kudrow et al., Headache 45, 1151 (2005). Review of clinical experience: M. Goldman, S. Schutzer, Formulary 37, 68-77 (2002); of clinical efficacy and safety: G. P. Joshi, Expert Rev. Neurother. 5, 11-24 (2005).
Properties: Crystals, mp 155-157°. Soly at 25°(mg/ml): water 10 (pH 7.0). Sol in methanol, ethanol; freely sol in organic solvents and alkaline (pH = 12) aqueous solns.
Melting point: mp 155-157°
Therap-Cat: Anti-inflammatory; analgesic.
Keywords: Anti-inflammatory (Nonsteroidal); Cyclooxygenase-2 Selective Inhibitor; Analgesic (Non-Narcotic).