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CAS No 18683-91-5 , 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol

  • Name: 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol
  • Synonyms: Ambroxol [INN:BAN]; Ambroxolum [INN-Latin]; Bromhexine-metabolite VIII;18683-91-5; NA-872; Bisolvon metabolite VIII;4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol;
  • CAS Registry Number:
  • Melting Point: 233-234 C
  • Density: 1.7 g/cm3
  • Refractive index: 1.654
  • Safety Statements: R22,
  • Hazard Symbols: Xn:Harmful;
  • EINECS: 242-500-3
  • Molecular Weight: 378.10282
  • InchiKey: JBDGDEWWOUBZPM-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H18Br2N2O/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-
    10/h5-6,10-11,17-18H,1-4,7,16H2
  • Risk Statements: S36,
  • Molecular Formula: C13H18Br2N2O
  • Molecular Structure:CAS No:18683-91-5 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol

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18683-91-5 Ambroxol Hcl

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18683-91-5 ACEBROPHYLLINE INTERMEDIATE: AMBROXOL

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18683-91-5 AMBROXOL HCL

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References of 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol
Title: Ambroxol
CAS Registry Number: 18683-91-5
CAS Name: 4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol
Synonyms: N-(trans-p-hydroxycyclohexyl)-(2-amino-3,5-dibromobenzyl)amine
Manufacturers' Codes: NA-872
Molecular Formula: C13H18Br2N2O
Molecular Weight: 378.10
Percent Composition: C 41.30%, H 4.80%, Br 42.27%, N 7.41%, O 4.23%
Literature References: Metabolite of bromhexine, q.v. Structure: E. Schraven et al., Eur. J. Pharmacol. 7, 445 (1967). Synthesis: J. Keck, Ann. 707, 107 (1967); FR 1522709; J. Keck et al., US 3536713 (1968, 1970 both to Thomae). Toxicity: S. Püschmann, R. Engelhorn, Arzneim.-Forsch. 28, 889 (1978). Series of articles on pharmacology, metabolism, and clinical studies: ibid. 889-935; on pharmacology and clinical efficacy of combination with amoxicillin, q.v., in bronchopulmonary disease: ibid. 37, 965-971 (1987). Symposium on pharmacology and efficacy in multicenter studies: Respiration 51, Suppl. 1, 1-68 (1987).
 
Derivative Type: Hydrochloride
CAS Registry Number: 23828-92-4
Trademarks: Abramen (Mepha); Ambril (Cascan); Bronchopront (Mack, Illert.); Duramucal (Durachemie); Fluibron (Chiesi); Fluixol (Ripari-Gero); Frenopect (Hefa); Lindoxyl (Lindopharm); Motosol (Europharma); Mucofar (Farmakos); Mucosan (Fher); Mucosolvan (Thomae); Mucoclear (Mundipharma); Mucovent (Byk Gulden); Pect (Rentschler); Solvolan (Krka); Stas-Hustenl?ser (Stada); Surbronc (Boehringer, Ing.); Surfactal (Boehringer, Ing.)
Molecular Formula: C13H18Br2N2O.HCl
Molecular Weight: 414.56
Percent Composition: C 37.66%, H 4.62%, Br 38.55%, N 6.76%, O 3.86%, Cl 8.55%
Properties: Crystals from ethanol, mp 233-234.5° (dec). LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn).
Melting point: mp 233-234.5° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 268, 380 i.p.; 2720, 13400 orally (Püschmann, Engelhorn)
 
Therap-Cat: Expectorant.
Keywords: Expectorant.