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CAS No 192725-17-0 , Lopinavir Search by region : India

  • Name: Lopinavir
  • Synonyms: 1(2H)-Pyrimidineacetamide,N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2-oxo-, (aS)-;Intermediates of Lopinavir;Lopinavir;1(2H)-Pyrimidineacetamide,N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2-oxo-, [1S-[1R*(R*),3R*,4R*]]-;1(2H)-Pyrimidineacetamide,N-[(1S,3S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2-oxo-, (aS)- (9CI);Koletra;ABT 378;Aluviran;A157378.0;
  • CAS Registry Number:
  • Density: 1.163 g/cm3
  • Refractive index: 1.577
  • Molecular Weight: 628.80
  • InChI: InChI=1/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1
  • Molecular Formula: C37H48N4O5
  • Molecular Structure:CAS No:192725-17-0 Lopinavir

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192725-17-0 Lopinavir

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192725-17-0 Lopinavir

  • India Shreeji Pharma International [Manufacturers]
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References of Lopinavir
Title: Lopinavir
CAS Registry Number: 192725-17-0
CAS Name: (aS)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-a-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
Synonyms: (aS)-tetrahydro-N-[(aS)-a-[(2S,3S)-2-hydroxy-4-phenyl-3-[2-(2,6-xylyloxy)acetamido]butyl]phenethyl]-a-isopropyl-2-oxo-1(2H)-pyrimidineacetamide; (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl)amino-3-hydroxy-5-[2S-(1-tetrahydropyrimid-2-onyl)-3-methylbutanoyl]amino-1,6-diphenylhexane
Manufacturers' Codes: ABT-378; A-157378
Molecular Formula: C37H48N4O5
Molecular Weight: 628.80
Percent Composition: C 70.67%, H 7.69%, N 8.91%, O 12.72%
Literature References: HIV protease inhibitor; analog of ritonavir, q.v. Prepn: H. L. Sham et al., WO 9721685; idem et al., US 5914332 (1997, 1999 both to Abbott); E. J. Stoner et al., Org. Process Res. Dev. 3, 145 (1999). Protease inhibition and pharmacokinetics: H. L. Sham et al., Antimicrob. Agents Chemother. 42, 3218 (1998). In vitro metabolism study: G. N. Kumar et al., Drug Metab. Dispos. 27, 86 (1999). Pharmacokinetic enhancement by ritonavir: G. N. Kumar et al., ibid. 902. Clinical trial with ritonavir in HIV infection: S. Walmsley et al., N. Engl. J. Med. 346, 2039 (2002).
Properties: Colorless solid from ethyl acetate, mp 124-127°.
Melting point: mp 124-127°
 
Derivative Type: Mixture with ritonavir
Trademarks: Kaletra (Abbott)
 
Therap-Cat: Antiviral.
Keywords: HIV Protease Inhibitor; Antiviral; Peptidomimetics.