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CAS No 1953-02-2 , 2-(2-sulfanylpropanoylamino)acetic acid

  • Name: 2-(2-sulfanylpropanoylamino)acetic acid
  • Synonyms: Acadione; Mucolysin; Captimer; Thiopronine; N-(2-Mercaptopropionyl)glycine;2-(2-sulfanylpropanoylamino)acetic acid; Capen; Thiola; Epatiol; 1953-02-2;
  • CAS Registry Number:
  • Melting Point: 93-98 °C
  • Density: 1.294 g/cm3
  • Refractive index: 1.518
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 217-778-4
  • Molecular Weight: 163.19486
  • InchiKey: YTGJWQPHMWSCST-UHFFFAOYSA-N
  • InChI: InChI=1S/C5H9NO3S/c1-3(10)5(9)6-2-4(7)8/h3,10H,2H2,1H3,(H,6,9)(H,7,8)
  • Risk Statements: S36/37
  • Molecular Formula: C5H9NO3S
  • Molecular Structure:CAS No:1953-02-2 2-(2-sulfanylpropanoylamino)acetic acid

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1953-02-2 N-(2-MERCAPTOPROPIONYL)GLYCINE

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References of 2-(2-sulfanylpropanoylamino)acetic acid
Title: Tiopronin
CAS Registry Number: 1953-02-2
CAS Name: N-(2-Mercapto-1-oxopropyl)glycine
Synonyms: N-(2-mercaptopropionyl)glycine; a-mercaptopropionylglycine
Trademarks: Acadione (Cassenne); Capen (Phoenix); Epatiol (Medici); Mucolysin (Proter); Thiola (Coop. Farm.); Thiosol (Coop. Farm.)
Molecular Formula: C5H9NO3S
Molecular Weight: 163.19
Percent Composition: C 36.80%, H 5.56%, N 8.58%, O 29.41%, S 19.65%
Literature References: Prepn: Mita et al., US 3246025 (1966 to Santen). Antidotal effects in mice: H. Fujimura et al., Nippon Yakurigaku Zasshi 60, 278 (1964), C.A. 62, 972h (1965). Anti-inflammatory pharmacology in animals: F. Capasso, Agents Actions 11, 741 (1981). Clinical trial in chronic hepatitis: F. Ichida et al., J. Int. Med. Res. 10, 325 (1982). Clinical comparison with D-penicillamine in rheumatoid arthritis: B. Amor et al., Arthritis Rheum. 25, 698 (1982); G. Pasero et al., ibid. 923.
Properties: Crystals from ethyl acetate, mp 95-97°. LD50 i.v. in mice: 2.1 g/kg (Fujimura).
Melting point: mp 95-97°
Toxicity data: LD50 i.v. in mice: 2.1 g/kg (Fujimura)
Therap-Cat: Antidote (heavy metal poisoning); hepatoprotectant; mucolytic.
Keywords: Antidote (Heavy Metal Poisoning); Hepatoprotectant; Mucolytic.