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CAS No 2011-67-8 , 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one

  • Name: 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
  • Synonyms: Hypnon; Erimin; Ro 5-3453; Nimetazepamum [INN-Latin]; 2011-67-8;Elimin; Nimetazepam [INN:JAN]; 1-Methylnitrazepam;1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one;
  • CAS Registry Number:
  • Melting Point: 156.5-7.5 °C
  • Flash Point: 280.7 ºC
  • Boiling Point: 540.5 ºC at 760 mmHg
  • Density: 1.33 g/cm3
  • Refractive index: 1.66
  • Water Solubility: 76.2 mg/L at 25 °C in water
  • Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. An anticonvulsant and muscle relaxant. Related to diazepam. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 280.7 ºC
  • EINECS: 217-931-5
  • Molecular Weight: 295.29272
  • InchiKey: GWUSZQUVEVMBPI-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)
    11-5-3-2-4-6-11/h2-9H,10H2,1H3
  • Molecular Formula: C16H13N3O3
  • Molecular Structure:CAS No:2011-67-8 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
References of 1-methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
Title: Nimetazepam
CAS Registry Number: 2011-67-8
CAS Name: 1,3-Dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
Synonyms: 1-methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 1-methylnitrazepam
Manufacturers' Codes: S-1530
Trademarks: Erimin (Sumitomo)
Molecular Formula: C16H13N3O3
Molecular Weight: 295.29
Percent Composition: C 65.08%, H 4.44%, N 14.23%, O 16.25%
Literature References: The desmethyl derivative of nitrazepam, q.v. Prepn: L. H. Sternbach et al., J. Med. Chem. 6, 261 (1963); E. Reeder, L. H. Sternbach, US 3109843; US 3144439; US 3141890; US 3243427 (1963, 1964, 1964, 1966 all to Hoffmann-La Roche); O. Keller et al., US 3121114; US 3203990 (1964, 1965 to Hoffmann-La Roche); Sorrentino, ZA 6706791 (1968 to Dumex), C.A. 70, 57916c (1969); Yamamoto et al., DE 1816046 (1970 to Sumitomo), C.A. 73, 120690d (1970); Inaba et al., Chem. Pharm. Bull. 19, 722 (1971). Pharmacology: S. Sakai et al., Arzneim.-Forsch. 22, 534 (1972).
Properties: Pale yellow plates from ethanol, mp 156.5-157.5°. uv max (methanol): 259, 308 nm (e 15800, 9600). LD50 in male, female mice, rats (mg/kg): 910, 750, 1150, 970 orally; 970, 840, 970, 980 i.p.; 1500, 1500, 1000, 1000 s.c. (Sakai).
Melting point: mp 156.5-157.5°
Absorption maximum: uv max (methanol): 259, 308 nm (e 15800, 9600)
Toxicity data: LD50 in male, female mice, rats (mg/kg): 910, 750, 1150, 970 orally; 970, 840, 970, 980 i.p.; 1500, 1500, 1000, 1000 s.c. (Sakai)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Sedative, hypnotic.
Keywords: Sedative/Hypnotic; Benzodiazepine Derivatives.