Home > Name List By 6 > 6-amino-5-fluoro-1H-pyrimidin-2-one Australia

CAS No 2022-85-7 , 6-amino-5-fluoro-1H-pyrimidin-2-one Search by region : Australia

  • Name: 6-amino-5-fluoro-1H-pyrimidin-2-one
  • Synonyms: 5-Fluorocystosine; Flucytosin; Fluorcytosine; Ancotil; flucytosine;6-amino-5-fluoro-1H-pyrimidin-2-one; 5-Fluorocytosin; 2022-85-7;5-Fluorocytosine; Ancobon; Fluocytosine;
  • CAS Registry Number:
  • Melting Point: 296 ºC
  • Flash Point: 296
  • Boiling Point: 298
  • Density: 1.73g/cm3
  • Refractive index: 1.613
  • Water Solubility: 1.5G/100ML (25 ºC)
  • Safety Statements: R40
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 296
  • EINECS: 217-968-7
  • Molecular Weight: 129.092463
  • InchiKey: XRECTZIEBJDKEO-UHFFFAOYSA-N
  • InChI: InChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)
  • Risk Statements: S36/37;S45
  • Molecular Formula: C4H4FN3O
  • Molecular Structure:CAS No:2022-85-7 6-amino-5-fluoro-1H-pyrimidin-2-one

Related products

Select to

2022-85-7 5-Fluorocytosine

  • 5-Fluorocytosine, 97%+
  • Australia Advanced Molecular Technologies Pty Ltd [Manufacturer]
  • Tel: +61 3 9565 1141
  • Fax: +61 3 9565 1149
  • Address: 11 Duerdin Street Clayton VIC 3168 3168 ClaytonAUSTRALIA Clayton,nullAustralia
Contact Supplier

Select to

1/1
References of 6-amino-5-fluoro-1H-pyrimidin-2-one
Title: Flucytosine
CAS Registry Number: 2022-85-7
CAS Name: 4-Amino-5-fluoro-2(1H)-pyrimidinone
Synonyms: 5-fluorocytosine; 5-FC
Manufacturers' Codes: Ro-2-9915
Trademarks: Alcobon (Roche); Ancobon (Roche); Ancotil (Roche)
Molecular Formula: C4H4FN3O
Molecular Weight: 129.09
Percent Composition: C 37.22%, H 3.12%, F 14.72%, N 32.55%, O 12.39%
Literature References: Prepn: Duschinsky et al., J. Am. Chem. Soc. 79, 4559 (1957); Heidelberger, Duschinsky, US 2802005 (1957); Duschinsky, Heidelberger, US 2945038 and Duschinsky, US 3040026 (1960, 1962 both to Hoffmann-La Roche); Undheim, Gacek, Acta Chem. Scand. 23, 294 (1969). Patents as a fungicide: Berger, Duschinsky, BE 628615 and US 3368938 (1963, 1968 both to Hoffmann-La Roche). Activity studies: Grunberg et al., Antimicrob. Agents Chemother. 1963, 566; Shadomy et al., ibid. 1968, 452; Grunberg et al., in 5th Int. Congr. Chemother., Proc. vol. IV, K. Spitzy, Ed. (Verlag Wiener Med. Akad., 1967, Austria) p 69. Metabolic studies: Koechlin et al., Biochem. Pharmacol. 15, 435 (1966). Clinical results: Utz et al., Antimicrob. Agents Chemother. 1968, 344; Warner et al., ibid. 1970, 473. Comprehensive description: E. H. Waysek, J. H. Johnson, Anal. Profiles Drug Subs. 5, 115-138 (1976).
Properties: Odorless, white crystalline solid, mp 295-297° (dec). uv max (0.1N HCl): 285 nm (e 8900). Soly in water: 1.5 g/100 ml at 25°C. pKa1: 3.26. LD50 in mice (mg/kg): >2000 orally and s.c.; 1190 i.p.; 500 i.v. (Grunberg, 1963).
Melting point: mp 295-297° (dec)
pKa: pKa1: 3.26
Absorption maximum: uv max (0.1N HCl): 285 nm (e 8900)
Toxicity data: LD50 in mice (mg/kg): >2000 orally and s.c.; 1190 i.p.; 500 i.v. (Grunberg, 1963)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic).