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CAS No 20554-84-1 , Parthenolide Search by region : Switzerland

  • Name: Parthenolide
  • Synonyms: 344906-67-8;Parthenolide;(-)-Parthenolide;Parthenolide(6CI,7CI);Germacra-1(10),11(13)-dien-12-oicacid, 4,5a-epoxy-6b-hydroxy-, g-lactone (8CI);
  • CAS Registry Number:
  • Melting Point: 115-116 ºC
  • Density: 1.13 g/cm3
  • Water Solubility: Soluble in chloroform, dichlormethane (5 mg/ml-clear, colorless solution),
  • Safety Statements: 22-24/25
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 248.32
  • InChI: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13-,15+/m0/s1
  • Risk Statements: S22;S24/25
  • Molecular Formula: C15H20O3
  • Molecular Structure:CAS No:20554-84-1 Parthenolide

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20554-84-1 PARTHENOLIDE

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References of Parthenolide
Title: Parthenolide
CAS Registry Number: 20554-84-1
CAS Name: (1aR,4E,7aS,10aS,10bS)-2,3,6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Synonyms: 4,5a-epoxy-6b-hydroxy-germacra-1(10),11(13)-dien-12-oic acid g-lactone
Molecular Formula: C15H20O3
Molecular Weight: 248.32
Percent Composition: C 72.55%, H 8.12%, O 19.33%
Literature References: Sesquiterpene lactone found in feverfew, q.v., and in other plants. Isolation from Chrysanthemum parthenium (L.) Bernh. Compositae and characterization: V. Herout et al., Chem. Ind. (London) 1959, 1069; M. Soucek et al., Collect. Czech. Chem. Commun. 26, 803 (1961); from Magnolia grandiflora L., Magnoliaceae: F. S. El-Feraly, Y.-M. Chan, J. Pharm. Sci. 67, 347 (1978). Revised structure and spectral analysis: T. R. Govindachari et al., Tetrahedron 21, 1509 (1965). Absolute configuration: A. S. Bawdekar et al., Tetrahedron Lett. 1966, 1225. Crystal structure: A. Quick, D. Rogers, J. Chem. Soc. Perkin Trans. 2 4, 465 (1976). HPLC determn: D. Strack et al., Z. Naturforsch. 35, 915 (1980). Cytotoxicity: K.-H. Lee et al., Cancer Res. 31, 1649 (1971); L. A. J. O'Neill et al., Br. J. Clin. Pharmacol. 23, 81 (1987).
Properties: Colorless plates, mp 115-116°. [a]D20 -81.4° (c = 1.04 in chloroform); [a]D22 -71.4° (c = 0.220 in CH2Cl2). uv max: 214 nm (log e 4.22).
Melting point: mp 115-116°
Optical Rotation: [a]D20 -81.4° (c = 1.04 in chloroform); [a]D22 -71.4° (c = 0.220 in CH2Cl2)
Absorption maximum: uv max: 214 nm (log e 4.22)