Home > Name List By 1 > 1-(3,3a,4,5,6, 6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea

CAS No 21187-98-4 , 1-(3,3a,4,5,6,
6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea

  • Name: 1-(3,3a,4,5,6,
    6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
  • Synonyms: Glimicron; Gliklazid; Gliclazidum [INN-Latin];1-(3,3a,4,5,6,
    6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea;Diamicron; Diaikron; Gliclazida [INN-Spanish]; Nordialex; 21187-98-4;
  • CAS Registry Number:
  • Melting Point: 163-169 ºC
  • Density: 1.35 g/cm3
  • Refractive index: 1.623
  • Water Solubility: methylene chloride: soluble
  • Safety Statements: 25-26-36/37-53
  • Hazard Symbols: Xn,Xi
  • EINECS: 244-260-5
  • Molecular Weight: 323.41054
  • InchiKey: BOVGTQGAOIONJV-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,
    21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,
    16,17,19)
  • Risk Statements: 21-36/38-46-62-63
  • Molecular Formula: C15H21N3O3S
  • Molecular Structure:CAS No:21187-98-4 1-(3,3a,4,5,6,<br />6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea

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References of 1-(3,3a,4,5,6,
6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
Title: Gliclazide
CAS Registry Number: 21187-98-4
CAS Name: N-[[(Hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Synonyms: 1-(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea; N-(4-methylbenzenesulfonyl)-N￠-(3-azabicyclo[3.3.0]oct-3-yl)urea; 1-(3-azabicyclo[3.3.0]oct-3-yl)-3-(p-tolylsulfonyl)urea
Manufacturers' Codes: S-1702
Trademarks: Diamicron (Servier); Glimicron (Dainippon); Nordialex (Pharmacodex)
Molecular Formula: C15H21N3O3S
Molecular Weight: 323.41
Percent Composition: C 55.71%, H 6.54%, N 12.99%, O 14.84%, S 9.91%
Literature References: Prepn: Beregi et al., FR 1510714 and US 3501495 (1968 and 1970, both to Sci. Union & Co.-Soc. Franc. Rech. Med.). Series of articles on pharmacology: Arzneim.-Forsch. 22, 1686-1695 (1972). Toxicity data: J. Duhault et al., ibid. 1682. Review of pharmacology, efficacy: B. Holmes et al., Drugs 27, 301 (1984).
Properties: Crystals from anhydrous ethanol, mp 180-182°. LD50 orally in mice: >3 g/kg (Duhault).
Melting point: mp 180-182°
Toxicity data: LD50 orally in mice: >3 g/kg (Duhault)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.