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CAS No 21256-18-8 , 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid Search by region : China

  • Name: 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
  • Synonyms: Alvo;3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid; Oxaprozina [INN-Spanish]; Oxaprozine [INN-French]; Voir; Oxaprozinum;Daypro; 21256-18-8; Deflam; Oxaprozinum [INN-Latin];
  • CAS Registry Number:
  • Melting Point: 158-159 ºC
  • Density: 1.222 g/cm3
  • Refractive index: 1.595
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 244-296-1
  • Molecular Weight: 293.3166
  • InchiKey: OFPXSFXSNFPTHF-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-
    9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
  • Risk Statements: S24/25;S36/37/39
  • Molecular Formula: C18H15NO3
  • Molecular Structure:CAS No:21256-18-8 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid

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21256-18-8 Oxaprozin

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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21256-18-8 Oxaprozin

  • China Boronsyn Co.,Ltd [Manufacturer]
  • Tel: +86-21-58407925
  • Fax: +86-21-58408291
  • Address: 1213 JunMin Road,Pudong,China null,nullChina
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21256-18-8 Oxaprozin

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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21256-18-8 Oxaprozin

  • China Xilin Chemical Group Co., Ltd null
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, null,nullChina
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21256-18-8 Oxaprozin

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21256-18-8 OXAPROZIN

  • China HuaiBei SanHe Developing Co., Ltd. [Manufacturers]
  • Tel: 86-561-3191113
  • Fax: +86-561-3192253
  • Address: Room 201,Building ZY-1,GuCheng Road,Huaibei,Anhui,China null,anhuiChina
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21256-18-8 Oxaprozin

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21256-18-8 Oxaprozin

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21256-18-8 OXAPROZIN

  • China Shanghai Union BioChem Co., Ltd [Manufacturer]
  • Tel: 86 21 50792295/ 86 21 50792833
  • Fax: 86 21 50792833
  • Address: Room 524, No. 333, Cailun Rd.,
    Zhangjiang Hi-tech,
    Pudong, Shanghai, China null,nullChina
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21256-18-8 Oxaprozin

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References of 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanoic acid
Title: Oxaprozin
CAS Registry Number: 21256-18-8
CAS Name: 4,5-Diphenyl-2-oxazolepropanoic acid
Synonyms: b-(4,5-diphenyloxazol-2-yl)propionic acid
Manufacturers' Codes: Wy-21743
Trademarks: Alvo (Taisho); Daypro (Pfizer)
Molecular Formula: C18H15NO3
Molecular Weight: 293.32
Percent Composition: C 73.71%, H 5.15%, N 4.78%, O 16.36%
Literature References: First description of anti-inflammatory properties: K. Brown et al., Nature 219, 164 (1968). Prepn: FR 2001036 (1969 to Inst. Farm. Serono), C.A. 72, 66930w (1970); K. Brown, GB 1206403 and US 3578671 (1970, 1971 both to Wyeth). Biochemical properties: M. W. Whitehouse et al., Biochem. Pharmacol. 20, 2309 (1971). Metabolism: F. W. Janssen et al., Drug Metab. Dispos. 6, 465 (1978). Pharmacology: D. A. Shriver et al., Toxicol. Appl. Pharmacol. 42, 75 (1977); F. Awouters et al., J. Pharm. Pharmacol. 30, 41 (1978). Clinical studies: R. Jamar, J. Dequeker, Curr. Med. Res. Opin. 5, 433 (1978); J. A. Hubsher et al., J. Int. Med. Res. 7, 69 (1979); eidem, Arthritis Rheum. 25, S117 (1982). Protein binding and clearance: C. A. Homon et al., Agents Actions 12, 211 (1982). Symposium on pharmacology and clinical efficacy: Semin. Arthritis Rheum. 15, Suppl. 3, 1-107 (1986). Review of mechanism of action and clinical efficacy: F. Dallegri et. al., Expert Opin. Pharmacother. 6, 777-785 (2005).
Properties: Crystals from methanol, mp 160.5-161.5°. Slightly sol in alcohol. Insol in water. Partition coefficient (octanol/water): 4.8 (pH 7.4). pKa 4.3.
Melting point: mp 160.5-161.5°
pKa: pKa 4.3
Log P: Partition coefficient (octanol/water): 4.8 (pH 7.4)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives.