Home > Name List By other > (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3, 4-diol

CAS No 21679-14-1 , (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,
4-diol

  • Name: (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,
    4-diol
  • Synonyms: EINECS 244-525-5; CCRIS 3382; HSDB 6964;21679-14-1;(2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,
    4-diol; F-Ara-A; Fludarabinum [Latin]; Fludarabina [Spanish]; Fludarabine [INN];
  • CAS Registry Number:
  • Flash Point: 405.8°C
  • Boiling Point: 747.3°Cat760mmHg
  • Density: 2.17g/cm3
  • Refractive index: 1.876
  • Safety Statements: R23/24/25;R36/37/38;R39
  • Flash Point: 405.8°C
  • EINECS: 244-525-5
  • Molecular Weight: 285.231783
  • InchiKey: HBUBKKRHXORPQB-FJFJXFQQSA-N
  • InChI: InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-
    17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1
  • Risk Statements: S26;S36/37;S45
  • Molecular Formula: C10H12FN5O4
  • Molecular Structure:CAS No:21679-14-1 (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,<br />4-diol

Related products

Search by region :

Select to

21679-14-1 Fludarabine (base)

  • China Xilin Chemical Group Co., Ltd null
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, null,nullChina
Contact Supplier

21679-14-1 Fludarabine (base)

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
Contact Supplier

21679-14-1 Fludarabine

  • China shanghai sphchem co.,ltd [Manufacturers]
  • Tel: +86-21-56491756 13512199871
  • Fax: 0
  • Address: NO.133, Wuye, Yangxin Road ,Shanghai China shanghai,shanghai ChinaChina
Contact Supplier

21679-14-1 Fludarabine

  • Fludarabine
  • Canada General Intermediates of Canada, Inc. [Manufacturer]
  • Tel: 780-483-2783
  • Fax: 780-483-2971
  • Address: General Intermediates of Canada, Inc.
    17303 - 108 Avenue
    Edmonton, Alberta
    CANADA T5S 1G2 null,nullCanada
Contact Supplier

21679-14-1 FLUDARABINE

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA null,nullChina
Contact Supplier

21679-14-1 Fludarabine

  • Fludarabine
  • China Hangzhou Pharma & Chem Co., Ltd. [Manufacturer]
  • Tel: +86 571 87040515
  • Fax: +86 571 87214761
  • Address: Hangzhou Pharma & Chem Co., Ltd.
    139 Qingchun Road, Hangzhou City,
    Zhejiang, China 310003 null,nullChina
Contact Supplier

21679-14-1 Fludarabine Phosphate, 99%

  • Fludarabine Phosphate, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,nullChina
Contact Supplier

21679-14-1 2-FLUORO-9-β-D-ARABINOFURANOSYLADENINE (FLUDARABINE; F-ARA-A)

  • United States NetQem, LLC [Manufacturer]
  • Tel: (919) 544-4122
  • Fax: (919) 544-4109
  • Address: NetQem, LLC
    P.O. Box 12091
    Research Triangle Park
    NC 27709, USA null,nullUnited States
Contact Supplier

21679-14-1 Fludarabine (base)

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
Contact Supplier

21679-14-1 Fludarabine

  • Hong kong LEO CHEMICAL (HONG KONG) CO., LTD [Manufacturer]
  • Tel: 86-519-85098858/ 86-519-85098877
  • Fax: 86-519-85098888/8889
  • Address: Hong Kong Office :
    LEO CHEMICAL (HONG KONG) CO., LTD
    MNJ2070, RM1602,
    OMEGA PLAZA, 32 DUNDAS STREET,
    MONKOK, KL, HONG KONG null,nullHong kong
Contact Supplier

Select to

3/12
Previous 1 2 3 4 5 6 7 8 9 10 Next
References of (2R,3S,4S,5R)-2-(6-amino-2-fluoropurin-9-yl)-5-(hydroxymethyl)oxolane-3,
4-diol
Title: Fludarabine
CAS Registry Number: 21679-14-1
CAS Name: 9-b-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine
Synonyms: 9-b-D-arabinofuranosyl-2-fluoroadenine; 2-fluorovidarabine; 2-fluoro-9-b-D-arabinofuranosyladenine; 2-F-araA
Manufacturers' Codes: NSC-118218; NSC-118218-H
Molecular Formula: C10H12FN5O4
Molecular Weight: 285.23
Percent Composition: C 42.11%, H 4.24%, F 6.66%, N 24.55%, O 22.44%
Literature References: Adenosine deaminase-resistant purine nucleoside antimetabolite. Prepn and in vitro cytotoxicity: J. A. Montgomery, K. Hewson, J. Med. Chem. 12, 498 (1969). Improved prepn: J. A. Montgomery et al., J. Heterocycl. Chem. 16, 157 (1979); J. A. Montgomery, US 4210745 (1980 to U.S. Dept. Health, Education and Welfare). Inhibition of DNA synthesis and in vivo antileukemic activity: R. W. Brockman et al., Biochem. Pharmacol. 26, 2193 (1977). Metabolized to 5￠-monophosphate: R. W. Brockman et al., Cancer Res. 40, 3610 (1980). HPLC determn in human leukemia cells: V. Gandhi et al., J. Chromatogr. 413, 293 (1987). Prepn of 5￠-monophosphate: J. A. Montgomery, A. T. Shortnacy, US 4357324 (1982 to U.S. Dept. of Health and Human Services). Pharmacokinetics in humans: M. R. Hersh et al., Cancer Chemother. Pharmacol. 17, 277 (1986). Evaluation of therapeutic efficacy and CNS toxicity in acute refractory leukemia: R. P. Warrell, Jr., E. Berman, J. Clin. Oncol. 4, 74 (1986); H. G. Chun et al., Cancer Treat. Rep. 70, 1225 (1986). Series of articles on pharmacology and therapeutic use: Semin. Oncol. 17, Suppl. 8, 1-78 (1990).
Properties: Crystals from ethanol + water, mp 260°. [a]D25 +17 ±2.5° (c = 0.1 in ethanol). uv max (pH 1, pH 7, pH 13): 262, 261, 262 nm (e ′ 10-3 13.2, 14.8, 15.0). Sparingly sol in water, organic solvents.
Melting point: mp 260°
Optical Rotation: [a]D25 +17 ±2.5° (c = 0.1 in ethanol)
Absorption maximum: uv max (pH 1, pH 7, pH 13): 262, 261, 262 nm (e ′ 10-3 13.2, 14.8, 15.0)
 
Derivative Type: 5￠-Monophosphate
CAS Registry Number: 75607-67-9
Synonyms: 2-F-ara-AMP
Manufacturers' Codes: NSC-328002; NSC-312887
Trademarks: Fludara (Schering AG)
Molecular Formula: C10H13FN5O7P
Molecular Weight: 365.21
Percent Composition: C 32.89%, H 3.59%, F 5.20%, N 19.18%, O 30.67%, P 8.48%
Properties: Sol in water.
 
Therap-Cat: Phosphate as antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Purine Analogs.