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CAS No 2180-92-9 , 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Search by region : China

  • Name: 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
  • Synonyms: (+-)-Bupivacaine; Carbostesin;1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;Marcaine; DL-Bupivacaine; Bupivacainum; Anekain; cBupivacaine; Sensorcaine; Bloqueina;
  • CAS Registry Number:
  • Transport: UN 2811
  • Flash Point: 140.9°C
  • Boiling Point: 436°C at 760 mmHg
  • Density: 1.014g/cm3
  • Refractive index: 1.534
  • Safety Statements: R26/27/28;R38;R41
  • Hazard Symbols: T+: Very toxic;
  • Flash Point: 140.9°C
  • EINECS: 218-553-3
  • Molecular Weight: 288.42772
  • InchiKey: LEBVLXFERQHONN-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-
    15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
  • Risk Statements: S22;S26;S36/37/39;S45
  • Molecular Formula: C18H28N2O
  • Molecular Structure:CAS No:2180-92-9 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

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2180-92-9 Bupivacaine

  • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
  • Min. Order: 1000
  • FOB Price: USD1 - 1000 /
  • China Jinan Jiage Biological Technology Co, Ltd [Manufacturer, Trading Company]
  • Tel: 86-0531-15564141272
  • Fax: 86-0531-85826061
  • Address: NO28, Sankongqiao Road, Tianqiao District, Jinan jinan,ShandongChina
Contact Supplier

yc2016
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  • 2180-92-9 local anesthetic Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 1000 /
    • China Jinan Jiage Biological Technology Co, Ltd [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: NO28, Sankongqiao Road, Tianqiao District, Jinan jinan,ShandongChina
    Contact Supplier

    yc2016
  • i
  • 2180-92-9 local anesthetic Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 1000 /
    • China Jinan Jiage Biological Technology Co, Ltd [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: No 28, Sankongqiao Road, Tianqiao District, Jinan Jinan,ShandongChina
    Contact Supplier

    yc2016
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  • 2180-92-9 Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 1000 /
    • China Jinan Jiage Biological Techonglogy Co, Ltd. [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: NO28, Sankongqiao Road, Tainqiao District,Jian jinan,ShandongChina
    Contact Supplier

    yc2016
  • i
  • 2180-92-9 local anesthetic Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 1000 /
    • China Jinan Jiage Biological Techonglogy Co, Ltd. [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: NO28, Sankongqiao Road, Tainqiao District,Jian jinan,ShandongChina
    Contact Supplier

    yc2016
  • i
  • 2180-92-9 Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 10000 /
    • China Jinan Jiage Biological Techonlogy Co, Ltd [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: No 28 Sankongqiao Road, Tianqiao District, Jinan jinan,ShandongChina
    Contact Supplier

    yc2016
  • i
  • 2180-92-9 local anesthetic Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 1000 /
    • China Jinan Jiage Biological Techonlogy Co, Ltd [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: No 28 Sankongqiao Road, Tianqiao District, Jinan jinan,ShandongChina
    Contact Supplier

    yc2016
  • i
  • 2180-92-9 Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 10000 /
    • China Jinan Jiage Biological Technology Co, Ltd [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: No 28, Sankongqiao Road, Tianqiao District, Jinan Jinan,ShandongChina
    Contact Supplier

    yc2016
  • i
  • 2180-92-9 Bupivacaine

    • Bupivacaine Synonyms:MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarbo...
    • Min. Order: 1000
    • FOB Price: USD1 - 10000 /
    • China Jinan Jia Ge Biological Technology [Manufacturer, Trading Company]
    • Tel: 86-0531-15564141272
    • Fax: 86-0531-85826061
    • Address: No 28, Sankongqiao Street, Tianqiao District, jinan,ShandongChina

    2180-92-9 Biguanide

    • Product Name: Bupivacaine Synonyms: MARCAINE;BUPIVACAINE;BUPIVACAINE BASE;(.+/-.)-1-Butyl-2',6'-pipecoloxylidide;1-Butyl-2-(2,6-xylycarbamoyl)piperidine;1-Butyl-2',6'-pipecoloxylidide;1-butyl-2’,6’-pipecoloxylidide;1-butyl-n-(2,6-dimethylphenyl)-2-...
    • China Guangzhou Huao Chenical [Manufacturer, Trading Company]
    • Tel: 86-020-28165199
    • Address: 1102,Unit 16, Ocean Time, Nansha District , Guangzhou City ,Guangdong Province,China Zip:511458 Guangzhou,GuangdongChina
    Contact Supplier

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    References of 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
    Title: Bupivacaine
    CAS Registry Number: 2180-92-9
    CAS Name: 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
    Synonyms: dl-1-butyl-2¢,6¢-pipecoloxylidide; 1-n-butyl-2¢,6¢-dimethyl-2-piperidinecarboxanilide; dl-N-n-butylpipecolic acid 2,6-xylidide; 1-butyl-2-(2,6-xylylcarbamoyl)piperidine; dl-1-n-butylpiperidine-2-carboxylic acid 2,6-dimethylanilide
    Molecular Formula: C18H28N2O
    Molecular Weight: 288.43
    Percent Composition: C 74.95%, H 9.78%, N 9.71%, O 5.55%
    Literature References: Prepn: B. Ekenstam et al., Acta Chem. Scand. 11, 1183 (1957); B. T. Ekenstam, B. G. Pettersson, US 2955111 (1960 to AB Bofors). Resolution of isomers: B. F. Tullar, J. Med. Chem. 14, 891 (1971). Stereospecific synthesis: B. Adger et al., Tetrahedron Lett. 37, 6399 (1996). Pharmacology of racemate: F. Henn, R. Brattsand, Acta Anaesthesiol. Scand. Suppl. 21, 9 (1966), C.A. 66, 17863u (1967); of isomers: F. P. Luduena et al., Arch. Int. Pharmacodyn. 200, 359 (1972). Clinical pharmacokinetics: D. W. Blake et al., Anaesth. Intensive Care 22, 522 (1994). Comprehensive description: T. D. Wilson, Anal. Profiles Drug Subs. 19, 59-94 (1990). Review of use in spinal anesthesia: Acta Anaesthesiol. Scand. 35, 1-10 (1991). Review of pharmacology and clinical efficacy of levobupivacaine: K. J. McClellan, C. M. Spencer, Drugs 56, 355-362 (1998).
    Properties: mp 107.5-108°. pKa 8.09; also reported as 8.17. Partition coefficient: (oleyl alcohol/water) 1565; (n-heptane/pH 7.4 buffer) 27.5.
    Melting point: mp 107.5-108°
    pKa: pKa 8.09; also reported as 8.17
    Log P: Partition coefficient: (oleyl alcohol/water) 1565; (n-heptane/pH 7.4 buffer) 27.5
     
    Derivative Type: Hydrochloride monohydrate
    CAS Registry Number: 14252-80-3
    Manufacturers' Codes: AH-2250; LAC-43
    Trademarks: Carbostesin (AstraZeneca); Marcaine (AstraZeneca); Sensorcaine (AstraZeneca)
    Molecular Formula: C18H28N2O.HCl.H2O
    Molecular Weight: 342.90
    Percent Composition: C 63.05%, H 9.11%, N 8.17%, O 9.33%, Cl 10.34%
    Properties: White, odorless crystalline powder. mp 258.5°. Slightly sol in acetone, chloroform, ether. Soly (mg/ml): water 40; alcohol 125. LD50 in mice (mg/kg): 7.8 i.v., 82 s.c. (Henn, Brattsand).
    Melting point: mp 258.5°
    Toxicity data: LD50 in mice (mg/kg): 7.8 i.v., 82 s.c. (Henn, Brattsand)
     
    Derivative Type: (-)-Form
    CAS Registry Number: 27262-47-1
    Synonyms: Levobupivacaine; (S)-bupivacaine
    Properties: Crystals from isopropanol, mp 135-137°. [a]D25 -80.9° (c = 5 in methanol).
    Melting point: mp 135-137°
    Optical Rotation: [a]D25 -80.9° (c = 5 in methanol)
     
    Derivative Type: (-)-Form hydrochloride
    CAS Registry Number: 27262-48-2
    Trademarks: Chirocaine (Abbott)
    Molecular Formula: C18H28N2O.HCl
    Molecular Weight: 324.89
    Percent Composition: C 66.54%, H 9.00%, N 8.62%, O 4.92%, Cl 10.91%
    Properties: mp 255-257°. [a]D25 -12.3° (c = 2 in water).
    Melting point: mp 255-257°
    Optical Rotation: [a]D25 -12.3° (c = 2 in water)
     
    Therap-Cat: Anesthetic (local).
    Keywords: Anesthetic (Local).