CAS No 22232-54-8 , ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate Search by region : Germany

Name: ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate
Synonyms: Neo-Mercazole; Basolest; Atirozidina;ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate;Athyromazole; Mertiran; Neomercazole; Carbotiroid; Neo-Thyreostat; Carbimazol;
CAS Registry Number:22232-54-8
Transport: 3335
Melting Point: 32
Boiling Point: 130
Density: 1.050
Refractive index: 1.611
Safety Statements: 22-36/37/39
EINECS: 244-854-4
Molecular Weight: 186.2315
InchiKey: CFOYWRHIYXMDOT-UHFFFAOYSA-N
InChI: InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3
Risk Statements: 22-36-43
Molecular Formula: C₇H₁₀N₂O₂S
Molecular Structure:

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References of ethyl 3-methyl-2-sulfanylideneimidazole-1-carboxylate

Title: Carbimazole
CAS Registry Number: 22232-54-8
CAS Name: 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic acid ethyl ester
Synonyms: 1-ethoxycarbonyl-3-methyl-2-thio-4-imidazoline; ethyl 3-methyl-2-thioimidazoline-1-carboxylate; 1-methyl-3-carbethoxy-2-thioglyoxalone; athyromazole
Trademarks: Neo-mercazole (Roche); Neo-Thyreostat (Herbrand)
Molecular Formula: C7H10N2O2S
Molecular Weight: 186.23
Percent Composition: C 45.15%, H 5.41%, N 15.04%, O 17.18%, S 17.22%
Literature References: Thyroid inhibitor. Prepn: Rimington et al., US 2671088, reissued as US RE 24505; US 2815349 (1954, 1958, 1957, all to Natl. Res. Dev. Corp.); Baker, J. Chem. Soc. 1958, 2387. Clinical efficacy in Graves' disease: J. Duprey et al., Presse Med. 17, 1124 (1988).
Properties: Crystalline powder with characteristic odor; tasteless at first, followed by bitter taste; mp 122-125°. Sol (at 20°) in 500 parts of water; in 50 parts of ethanol; in 330 parts of ether; in 3 parts of chloroform; in 17 parts of acetone. uv max in 0.1N HCl : water (1:8): 291 nm; in 0.1N H2SO4: 227 nm and 291 nm (E1%1cm 557).
Melting point: mp 122-125°
Absorption maximum: uv max in 0.1N HCl : water (1:8): 291 nm; in 0.1N H2SO4: 227 nm and 291 nm (E1%1cm 557)
Therap-Cat: Antihyperthyroid.
Keywords: Antihyperthyroid.