Home > Name List By 5 > 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol

CAS No 22232-71-9 , 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol

  • Name: 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol
  • Synonyms: Mazanor; Sanorex; Mazindolum [INN-Latin]; Mazildene; 22232-71-9; Dimagrir; Teronac;5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol; Mazindole; Magrilon;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 2
  • Melting Point: 215-217 ºC
  • Flash Point: 228.9 ºC
  • Boiling Point: 454.9 ºC at 760 mmHg
  • Density: 1.39
  • Refractive index: 1.704
  • Water Solubility: DMSO: 10 mg/mL
  • Safety Statements: Poison by ingestion. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. An FDA proprietary drug. An anorectic drug. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • Hazard Symbols: T: Toxic;
  • Flash Point: 228.9 ºC
  • EINECS: 244-857-0
  • Molecular Weight: 284.74022
  • InchiKey: ZPXSCAKFGYXMGA-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-
    9-10-19(15)16/h1-8,20H,9-10H2
  • Risk Statements: 23/24/25
  • Molecular Formula: C16H13ClN2O
  • Molecular Structure:CAS No:22232-71-9 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol
References of 5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol
Title: Mazindol
CAS Registry Number: 22232-71-9
CAS Name: 5-(4-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol
Synonyms: 5-(4-chlorophenyl)-2,3-dihydro-5-hydroxy-5H-imidazo[2,1-a]isoindole
Manufacturers' Codes: SaH-42548
Trademarks: Magrilon (Sintyal); Mazildene (Farmochim. Ital.); Sanorex (Novartis); Teronac (Novartis)
Molecular Formula: C16H13ClN2O
Molecular Weight: 284.74
Percent Composition: C 67.49%, H 4.60%, Cl 12.45%, N 9.84%, O 5.62%
Literature References: Prepn: W. J. Houlihan, DE 1814540 C.A. 71, 81368s (1969); W. J. Houlihan, M. K. Eberle, DE 1930488; eidem, US 3597445 (1969, 1970, 1970 all to Sandoz); T. S. Sulkowski, US 3763178 (1973 to American Home Prod.). Clinical trials as appetite depressant: C. Sirtori et al., Am. J. Med. Sci. 261, 341 (1971); A. J. Hadler, J. Clin. Pharmacol. 12, 453 (1972). Effect on human prolactin and growth hormone responses: D. A. Thompson et al., Metabolism 30, 1015 (1981). Clinical evaluation in Duchenne muscular dystrophy: P. J. Collipp et al., J. Med. Genet. 21, 254 (1984).
Properties: White crystalline solid from ethanol, mp 215-217° (Sulkowski); also reported as crystals from acetone-hexane, mp 198-199° (Houlihan, Eberle). uv max (95% ethanol): 223, 268.5, 272 nm (e 19000, 4400, 4400). Sol in ethanol. Insol in water.
Melting point: mp 215-217° (Sulkowski); mp 198-199° (Houlihan, Eberle)
Absorption maximum: uv max (95% ethanol): 223, 268.5, 272 nm (e 19000, 4400, 4400)
NOTE: This is a controlled substance (stimulant): 21 CFR, 1308.14.
Therap-Cat: Anorexic; CNS stimulant.
Keywords: Anorexic; CNS Stimulant.