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CAS No 23651-95-8 , Droxidopa Search by region : Germany

  • Name: Droxidopa
  • Synonyms: (-)-(2S,3R)-2-Amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionic acid;Droxidopa;
  • CAS Registry Number:
  • Flash Point: 286.3°C
  • Boiling Point: 549.8°Cat760mmHg
  • Density: 1.608g/cm3
  • Refractive index: 1.692
  • Flash Point: 286.3°C
  • Molecular Weight: 213.19
  • InChI: InChI=1/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8-/m0/s1
  • Molecular Formula: C9H11NO5
  • Molecular Structure:CAS No:23651-95-8 Droxidopa

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23651-95-8 Droxidopa

  • Droxidopa
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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References of Droxidopa
Title: Droxidopa
CAS Registry Number: 23651-95-8
CAS Name: threo-b,3-Dihydroxy-L-tyrosine
Synonyms: L-threo-3-(3,4-dihydroxyphenyl)serine; (-)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propionic acid; threo-dopaserine; L-threo-DOPS; L-DOPS
Manufacturers' Codes: SM-5688
Trademarks: Dops (Sumitomo)
Molecular Formula: C9H11NO5
Molecular Weight: 213.19
Percent Composition: C 50.70%, H 5.20%, N 6.57%, O 37.52%
Literature References: Synthetic amino acid precursor of norepinephrine, q.v. Prepn of racemate: K. W. Rosenmund, H. Dornsaft, Ber. 52B, 1734 (1919). Separation and resolution of diastereomers: B. Hegedüs et al., Helv. Chim. Acta 58, 147 (1975); B. Hegedüs, A. Krasso, US 3920728 (1975 to Hoffmann-La Roche). Improved process for production: N. Ohashi et al., US 4319040 (1982 to Sumitomo). Pharmacology of stereoisomers: G. Bartholini et al., J. Pharmacol. Exp. Ther. 193, 523 (1975). Clinical pharmacology of L-threo-form and clinical evaluation in familial amyloid polyneuropathy (FAP): T. Suzuki et al., Eur. J. Clin. Pharmacol. 17, 429 (1980). Reversed-phase chromatography determn in plasma and urine: F. Boomsma et al., J. Chromatogr. 427, 219 (1988). Pharmacokinetics in FAP: T. Suzuki et al., Eur. J. Clin. Pharmacol. 23, 463 (1982); in parkinsonism: T. Suzuki et al., Neurology 34, 1446 (1984). Metabolism to norepinephrine: T. Suzuki et al., Life Sci. 36, 435 (1985). Clinical studies in Parkinson's disease: N. Ogawa et al., J. Med. 16, 525 (1985); H. Narabayashi et al., Adv. Neurol. 45, 593 (1986).
Properties: Crystals from ethanol and ether, mp 232-235° (dec). [a]D20 -39° (c = 1 in 1N aq HCl). Also cited as crystals from water and L-ascorbic acid, mp 229-232° (dec) (Ohashi). [a]D20 -42.0° (c = 1 in 1N aq HCl).
Melting point: mp 232-235° (dec); mp 229-232° (dec) (Ohashi)
Optical Rotation: [a]D20 -39° (c = 1 in 1N aq HCl); [a]D20 -42.0° (c = 1 in 1N aq HCl)
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian.