Title: Phthalazine
CAS Registry Number: 253-52-1
Synonyms: 2,3-Benzodiazine; benzo[
d]pyridazine; b-phenodiazine
Molecular Formula: C8H6N2
Molecular Weight: 130.15
Percent Composition: C 73.83%, H 4.65%, N 21.52%
Literature References: Prepd by reduction of 1-chlorophthalazine with hydriodic acid and red phosphorus: Gabriel, Eschenbach,
Ber. 30, 3024 (1897); Paul,
Ber. 32, 2015 (1899); by redn of 1-hydrazinophthalazine: Armarego,
J. Appl. Chem. 11, 70 (1961); from
o-phthalaldehyde + hydrazine sulfate: Smith, Otremba,
J. Org. Chem. 27, 879 (1962); from 1,2-benzodinitrile: Carter, Cheeseman,
Org. Prep. Proced. Int. 6, 67 (1974).
Properties: Pale yellow needles from ether, mp 90-91°. bp 315-317° (dec); bp29 189°; bp17 175°. uv max (water): 218, 261, 292, 305 nm (log e 4.83, 3.53, 3.18, 3.11). Freely sol in water; sol in ethanol, methanol, benzene, ethyl acetate; less sol in ether. Practically insol in ligroin.
Melting point: mp 90-91°
Boiling point: bp 315-317° (dec); bp29 189°; bp17 175°
Absorption maximum: uv max (water): 218, 261, 292, 305 nm (log e 4.83, 3.53, 3.18, 3.11)
Derivative Type: Hydrochloride
Molecular Formula: C8H6N2.HCl
Molecular Weight: 166.61
Percent Composition: C 57.67%, H 4.23%, N 16.81%, Cl 21.28%
Properties: Needles from ether, mp 231° (efferv).
Melting point: mp 231° (efferv)
