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CAS No 25451-15-4 , (3-carbamoyloxy-2-phenylpropyl) carbamate Search by region : India

  • Name: (3-carbamoyloxy-2-phenylpropyl) carbamate
  • Synonyms: Felbamyl; Taloxa;Felbatol; Felbamatum; 2-Phenylpropane-1,3-diyl dicarbamate; Felbamato; 25451-15-4; 2-Phenyl-1,3-propanediol dicarbamate;(3-carbamoyloxy-2-phenylpropyl) carbamate;
  • CAS Registry Number:
  • Melting Point: 148-150ºC
  • Density: 1.275 g/cm3
  • Refractive index: 1.558
  • Water Solubility: soluble in alcohol
  • Safety Statements: Moderately toxic by intraperitoneal rex. Low toxicity by ingestion. Human systemic effects. When heated to decomposition it emits toxic vapors of NOx.
  • Hazard Symbols: Low toxicity by ingestion. Human systemic effects.
  • EINECS: 247-001-4
  • Molecular Weight: 238.23986
  • InchiKey: WKGXYQFOCVYPAC-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,
    9H,6-7H2,(H2,12,14)(H2,13,15)
  • Molecular Formula: C11H14N2O4
  • Molecular Structure:CAS No:25451-15-4 (3-carbamoyloxy-2-phenylpropyl) carbamate

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25451-15-4 Felbamate

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25451-15-4 FELBAMATE-D4

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References of (3-carbamoyloxy-2-phenylpropyl) carbamate
Title: Felbamate
CAS Registry Number: 25451-15-4
CAS Name: 2-Phenyl-1,3-propanediol dicarbamate
Synonyms: carbamic acid 2-phenyltrimethylene ester
Manufacturers' Codes: ADD-03055; W-554
Trademarks: Felbamyl (Wallace); Felbatol (Carter-Wallace); Taloxa (Schering-Plough)
Molecular Formula: C11H14N2O4
Molecular Weight: 238.24
Percent Composition: C 55.46%, H 5.92%, N 11.76%, O 26.86%
Literature References: Antiepileptic, structurally similar to meprobamate, q.v. Prepn: F. M. Berger, B. J. Ludwig, US 2884444 (1959 to Carter); B. J. Ludwig et al., J. Med. Chem. 12, 462 (1969). Use in treatment of epileptic seizures: R. D. Sofia, US 4978680 (1990 to Carter-Walace). HPLC determn in plasma: R. P. Remmel et al., Ther. Drug Monit. 12, 90 (1990). Pharmacology: E. A. Swinyard et al., Epilepsia 27, 27 (1986). Metabolism in animals: J. T. Yang et al., Drug Metab. Dispos. 19, 1126 (1991). Penetration of blood brain barrier: E. M. Cornford et al., Epilepsia 33, 944 (1992). Clinical pharmacokinetics: A. J. Wilensky et al., ibid. 26, 602 (1985). Clinical trial in refractory partial seizures: E. Faught et al., Neurology 43, 688 (1993). Efficacy in childhood epileptic encephalopathy (Lennox-Gastaut syndrome): F. J. Ritter et al., N. Engl. J. Med. 328, 29 (1993). Review of pharmacology, toxicology and clinical evaluation: R. D. Sofia et al., Epilepsy Res. Suppl. 3, 103-108 (1991).
Properties: White, odorless powder, mp 151-152°. Sparingly sol in water, methanol, ethanol, acetone and chloroform; freely sol in DMSO, 1-methyl-2-pyrrolidinone and DMF. LD50 i.p. in mice: 4000 mg/kg (Ludwig et al.).
Melting point: mp 151-152°
Toxicity data: LD50 i.p. in mice: 4000 mg/kg (Ludwig et al.)
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.