Home > Name List By other > (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxyl... Canada

CAS No 26787-78-0 , (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,
3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Search by region : Canada

  • Name: (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,
    3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Synonyms: Trimox;Amoxycillin;(2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,
    3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Amoxicilline; Amolin; Polymox; Amopenixin; Amoxicillin anhydrous; Moxal; Wymox;
  • CAS Registry Number:
  • Density: 1.54g/cm3
  • Safety Statements: R42/43
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 248-003-8
  • Molecular Weight: 365.40416
  • InchiKey: LSQZJLSUYDQPKJ-NJBDSQKTSA-N
  • InChI: InChI=1S/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12
    (21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,
    24)/t9-,10-,11+,14-/m1/s1
  • Risk Statements: S22;S36/37
  • Molecular Formula: C16H19N3O5S
  • Molecular Structure:CAS No:26787-78-0 (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,<br />3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

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References of (2S,5R,6R)-6-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,
3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Title: Amoxicillin
CAS Registry Number: 26787-78-0
CAS Name: (2S,5R,6R)-6-[[(2R)-Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Synonyms: (-)-6-[2-amino-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-[D(-)-a-amino-p-hydroxyphenylacetamido]penicillanic acid; a-amino-p-hydroxybenzylpenicillin; 6-(p-hydroxy-a-aminophenylacetamido)penicillanic acid; p-hydroxyampicillin; amoxycillin; AMPC
Trademarks: Helvamox (Helvepharm); Pasetocin (Kyowa); Penimox (IBSA); Supramox (Grñenthal); Zamocilline (Inpharzam)
Molecular Formula: C16H19N3O5S
Molecular Weight: 365.40
Percent Composition: C 52.59%, H 5.24%, N 11.50%, O 21.89%, S 8.78%
Literature References: Semi-synthetic antibiotic related to penicillin. Prepn: Nayler, Smith, GB 978178 (1964 to Beecham); eidem, US 3192198 (1965); Long, Nayler, DE 1942693 and GB 1241844 (1970 and 1971 to Beecham), C.A. 72, 90447q (1970). Resolution of isomers: Long et al., J. Chem. Soc. C 1971, 1920. Series of articles on activity, pharmacology, absorption and excretion: Antimicrob. Agents Chemother. 1970, 407-430. Review of antibacterial activity, pharmacokinetics and therapeutic use: R. N. Brogden et al., Drugs 18, 169-184 (1979). Comprehensive description: A. E. Bird, Anal. Profiles Drug Subs. Excip. 23, 1-52 (1994).
 
Derivative Type: Trihydrate
CAS Registry Number: 61336-70-7
Manufacturers' Codes: BRL-2333
Trademarks: Agram (Fabre); Alfamox (Teofarma); Amocilline (Inpharzam); Amodex (Bouchara); Amoram (Eastern); Amoxidin (Lagap); Amoxil (GSK); Amoxillat (Novartis); Amoxypen (Grñenthal); Ardine (Antibioticos); Bactox (Innotech); Betamox (Norbrook); Bristamox (BMS); Cuxacillin (TAD); Flemoxine (Yamanouchi); Gramidil (Dexo); Hiconcil (BMS); Larotid (Roche); Ospamox (Novartis); Polymox (BMS); Robamox (Wyeth); Sigamopen (Alpharma); Trimox (BMS); Velamox (GSK); Widecillin (Meiji); Wymox (Wyeth); Zimox (Pfizer)
Properties: Off-white crystalline powder. [a]D20 +246° (c = 0.1). uv max (ethanol): 230, 274 nm (e 10850, 1400); (0.1N HCl): 229, 272 nm (e 9500, 1080); (0.1N KOH): 248, 291 (e 2200, 3000). Solubility (mg/ml): water 4.0; methanol 7.5; abs ethanol 3.4. Insol in hexane, benzene, ethyl acetate, acetonitrile.
Optical Rotation: [a]D20 +246° (c = 0.1)
Absorption maximum: uv max (ethanol): 230, 274 nm (e 10850, 1400); (0.1N HCl): 229, 272 nm (e 9500, 1080); (0.1N KOH): 248, 291 (e 2200, 3000)
 
Derivative Type: Sodium salt
CAS Registry Number: 34642-77-8
Trademarks: Clamoxyl (GSK); Ibiamox (IBI)
Molecular Formula: C16H18N3NaO5S
Molecular Weight: 387.39
Percent Composition: C 49.61%, H 4.68%, N 10.85%, Na 5.93%, O 20.65%, S 8.28%
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins.