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CAS No 26807-65-8 , 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide

  • Name: 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
  • Synonyms: Tertensif; Bajaten; Tandix; Lozol; Veroxil; Fludex; Arifon; Indamol;4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide; Noranat;
  • CAS Registry Number:
  • Density: 1.51 g/cm3
  • Refractive index: 1.693
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx.
  • EINECS: 248-012-7
  • Molecular Weight: 365.83454
  • InchiKey: NDDAHWYSQHTHNT-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H16ClN3O3S/c1-10-8-11-4-2-3-5-14(11)20(10)19-16(21)12-6-7-13
    (17)15(9-12)24(18,22)23/h2-7,9-10H,8H2,1H3,(H,19,21)(H2,18,22,23)
  • Molecular Formula: C16H16ClN3O3S
  • Molecular Structure:CAS No:26807-65-8 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide

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References of 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Title: Indapamide
CAS Registry Number: 26807-65-8
CAS Name: 3-(Aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide
Synonyms: 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide; N-(3-sulfamyl-4-chlorobenzamido)-2-methylindoline
Manufacturers' Codes: S-1520; SE-1520
Trademarks: Bajaten (Merck KGaA); Fludex (Eutherapie); Indaflex (Lampugnani); Indamol (Aventis); Lozol (Aventis); Noranat (Novartis); Tandix (Biofarma); Veroxil (Baldacci)
Molecular Formula: C16H16ClN3O3S
Molecular Weight: 365.83
Percent Composition: C 52.53%, H 4.41%, Cl 9.69%, N 11.49%, O 13.12%, S 8.77%
Literature References: Prepn: Beregi et al., FR 2003311; eidem, US 3565911 (1969, 1971, both to Sci. Union et Cie, Soc. Franc. Recherche Med.). LC/MS determn in plasma: F. Albu et al., J. Chromatogr. B 816, 35 (2005). Pharmacology: Leary et al., Curr. Ther. Res. 15, 571 (1973); D. B. Campbell, R. A. Moore, Postgrad. Med. J. Suppl. 57, 7 (1981). Acute toxicity data: J. Kyncl et al., Arzneim.-Forsch. 25, 1491 (1975). Symposium on pharmacology and clinical efficacy: Am. J. Med. 84, Suppl. 1B, 1-111 (1988); Am. J. Cardiol. 65, Suppl. H, 1H-80H (1990). Comprehensive description: T. J. DiFeo, J. E. Shuster, Anal. Profiles Drug Subs. Excip. 23, 229-268 (1994).
Properties: Crystals from isopropanol/water, mp 160-162°. uv max (methanol): 242, 278, 286 nm (A1%1cm 630, 98, 100). Sol in methanol, acetic acid, ethyl acetate. Very slightly sol in chloroform. pKa (25°) 8.8 ± 0.2. LD50 in rats, mice, guinea pigs (mg/kg): 393-421, 410-564, 347-416 i.p.; 394-440, 577-635, 272-358 i.v.; >3000 all species orally (Kyncl).
Melting point: mp 160-162°
pKa: pKa (25°) 8.8 ± 0.2
Absorption maximum: uv max (methanol): 242, 278, 286 nm (A1%1cm 630, 98, 100)
Toxicity data: LD50 in rats, mice, guinea pigs (mg/kg): 393-421, 410-564, 347-416 i.p.; 394-440, 577-635, 272-358 i.v.; >3000 all species orally (Kyncl)
 
Derivative Type: Hemihydrate
Trademarks: Damide (Benedetti); Ipamix (Gentili); Natrilix (Servier); Pressural (Polifarma)
Molecular Formula: C16H16ClN3O3S.?H2O
Molecular Weight: 374.84
Percent Composition: C 51.27%, H 4.57%, Cl 9.46%, N 11.21%, O 14.94%, S 8.55%
 
Therap-Cat: Antihypertensive; diuretic.
Keywords: Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs.