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CAS No 27220-47-9 , 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole Search by region : Canada

  • Name: 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
  • Synonyms: Ecostatin cream; Pevaryl; Gyno-Pevaryl 150; Gyno-pevaryl;1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole; Spectazole cream; Palavale;Ecostatin; Ifenec; Spectazole;
  • CAS Registry Number:
  • Melting Point: 86.8 ºC
  • Density: 1.33 g/cm3
  • Water Solubility: soluble in water
  • Safety Statements: 24/25-36/37/39
  • Hazard Symbols: Xi
  • EINECS: 248-341-6
  • Molecular Weight: 381.6835
  • InchiKey: LEZWWPYKPKIXLL-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)
    16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
  • Risk Statements: 36/37/38
  • Molecular Formula: C18H15Cl3N2O
  • Molecular Structure:CAS No:27220-47-9 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole

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27220-47-9 ECONAZOLE NITRATE

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
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References of 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole
Title: Econazole
CAS Registry Number: 27220-47-9
CAS Name: 1-[2-[(4-Chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
Synonyms: 1-[2,4-dichloro-b-[(p-chlorobenzyl)oxy]phenethyl]imidazole
Manufacturers' Codes: SQ-13050
Molecular Formula: C18H15Cl3N2O
Molecular Weight: 381.68
Percent Composition: C 56.64%, H 3.96%, Cl 27.87%, N 7.34%, O 4.19%
Literature References: Prepn: Godefroi et al., J. Med. Chem. 12, 784 (1969); Godefroi, Heeres, DE 1940388; eidem, US 3717655 (1970, 1973 both to Janssen). Biological and toxicological properties: Thienpont et al., Arzneim.-Forsch. 25, 224 (1975). Review of antifungal activity and therapeutic efficacy: R. C. Heel et al., Drugs 16, 177-201 (1978). Comprehensive description: A. M. Dyas, H. Delargy, Anal. Profiles Drug Subs. Excip. 23, 125-152 (1994).
Properties: mp 86.8°.
Melting point: mp 86.8°
 
Derivative Type: Nitrate
CAS Registry Number: 24169-02-6
Manufacturers' Codes: R-14827
Trademarks: Epi-Pevaryl (Cilag-Chemie); Gyno-Pevaryl (Cilag-Chemie); Ifenec (Italfarmaco); Micofugal (Biopharma); Micogin (Crosara); Palavale (Otsuka); Pargin (Gibipharma); Pevaryl (Cilag); Spectazole (Ortho)
Molecular Formula: C18H15Cl3N2O.HNO3
Molecular Weight: 444.70
Percent Composition: C 48.62%, H 3.63%, Cl 23.92%, N 9.45%, O 14.39%
Properties: White, odorless crystals from a mixture of 2-propanol, methanol and diisopropyl ether, mp 162°. uv max (methanol): 202, 225 nm. uv max (methanol): 265, 271, 280 nm (A1%1cm 9.4, 9.7, 4.9). Soly at 20° (g/100 ml): water <0.1; ethanol (96%) 2.0; acetone 1.5. LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont).
Melting point: mp 162°
Absorption maximum: uv max (methanol): 202, 225 nm; uv max (methanol): 265, 271, 280 nm (A1%1cm 9.4, 9.7, 4.9)
Toxicity data: LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont)
 
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.