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CAS No 27589-33-9 , 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)
benzenesulfonamide

  • Name: 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)
    benzenesulfonamide
  • Synonyms: Diart; Azosemidum;Azosemid; Azosemidum [INN-Latin]; 27589-33-9; Azosemide [USAN:INN:JAN]; Azosemida; Azosemida [INN-Spanish]; PLE 1053;2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)
    benzenesulfonamide;
  • CAS Registry Number:
  • Flash Point: 359.6°C
  • Boiling Point: 671.1°Cat760mmHg
  • Density: 1.661g/cm3
  • Refractive index: 1.709
  • Safety Statements: Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx.
  • Flash Point: 359.6°C
  • EINECS: 248-549-7
  • Molecular Weight: 370.83774
  • InchiKey: HMEDEBAJARCKCT-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-
    12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19)
  • Molecular Formula: C12H11ClN6O2S2
  • Molecular Structure:CAS No:27589-33-9 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)<br />benzenesulfonamide

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References of 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)
benzenesulfonamide
Title: Azosemide
CAS Registry Number: 27589-33-9
CAS Name: 2-Chloro-5-(1H-tetrazol-5-yl)-4-[(2-thienylmethyl)amino]benzenesulfonamide
Synonyms: 2-chloro-5-(2H-tetrazol-5-yl)-N4-2-thenylsulfanilamide; 5-(4￠-chloro-2￠-thenylamino-5￠-sulfamoylphenyl)tetrazole
Manufacturers' Codes: Ple-1053
Trademarks: Diart (Boehringer, Mann.); Luret (Sanofi Winthrop)
Molecular Formula: C12H11ClN6O2S2
Molecular Weight: 370.84
Percent Composition: C 38.87%, H 2.99%, Cl 9.56%, N 22.66%, O 8.63%, S 17.29%
Literature References: Prepn: A. Popelak et al., DE 1815922; eidem, US 3665002 (1968, 1972 both to Boehringer, Mann.). Separation and analysis in blood and urine by HPLC: R. Seiwell, C. Brater, J. Chromatogr. 182, 257 (1980). Sites of action: C. Brater, Clin. Pharmacol. Ther. 25, 428 (1979). Clinical and pharmacological studies: F. Krueck et al., Eur. J. Clin. Pharmacol. 14, 153 (1978). Diuretic effect in animals: J. Greven, O. Heidenreich, Arzneim.-Forsch. 31, 346, 350 (1981).
Properties: Crystals, mp 218-221°.
Melting point: mp 218-221°
Therap-Cat: Diuretic.
Keywords: Diuretic; Sulfonamide Derivatives.