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CAS No 28395-03-1 , 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid

  • Name: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
  • Synonyms: Fontego; Burinex; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid; Segurex; Lunetoron; 28395-03-1; Fordiuran;Bumex;3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid;
  • CAS Registry Number:
  • Melting Point: 230-231 °C
  • Flash Point: 299.3°C
  • Boiling Point: 571.2°Cat760mmHg
  • Density: 1.347g/cm3
  • Refractive index: 1.612
  • Water Solubility: (Soluble in ethanol, DMSO)
  • Safety Statements: Poison by ingestion, subcutaneous, and intravenous routes. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of SOx and NOx.
  • Flash Point: 299.3°C
  • EINECS: 249-004-6
  • Molecular Weight: 364.4161
  • InchiKey: MAEIEVLCKWDQJH-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,
    22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,
    18,22,23)
  • Molecular Formula: C17H20N2O5S
  • Molecular Structure:CAS No:28395-03-1 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid

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References of 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Title: Bumetanide
CAS Registry Number: 28395-03-1
CAS Name: 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
Synonyms: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Manufacturers' Codes: PF-1593; Ro-10-6338
Trademarks: Bumex (Roche); Burinex (Leo Pharm); Butinat (Gramon); Fontego (Polifarma); Fordiuran (Thomae); Lunetoron (Sankyo)
Molecular Formula: C17H20N2O5S
Molecular Weight: 364.42
Percent Composition: C 56.03%, H 5.53%, N 7.69%, O 21.95%, S 8.80%
Literature References: Prepn: P. W. Feit, DE 1964503 and DE 1964504; idem, US 3806534 (1970, 1970, 1974 all to L?vens Kemiske Fabrik); idem, J. Med. Chem. 14, 432 (1971). Pharmacology: E. H. Oestergaard et al., Arzneim.-Forsch. 22, 66 (1972). HPLC and GC/MS determn in urine: C. Y. Gradeen et al., J. Anal. Toxicol. 14, 123 (1990). Review of pharmacology and therapeutic use: A. Ward, R. C. Heel, Drugs 28, 426-464 (1984). Series of articles on pharmacokinetics and comparative clinical studies in combination therapy: Curr. Ther. Res. 50, Suppl. A, 1-82 (1991). Comprehensive description: P. N. V. Tata et al., Anal. Profiles Drug Subs. Excip. 22, 107-144 (1993).
Properties: Crystals from aq ethanol, mp 230-231°. pK1 3.6, pK2 7.7. Soly (mg/ml): water 0.1; ethanol 30.6; propylene glycol 18.7; dimethylacetamide >500; methanol 76.5; benzene 0.4; benzyl alcohol 21.6; acetone 50.2. Sol in alkaline solns. uv max (water): 260, 220 nm (E1% 18.9, 17.1); (0.1 N NaOH): 326 nm; (methanol): 270, 345 nm. LD50 i.v. in mice: 330 mg/kg (Oestergaard).
Melting point: mp 230-231°
pKa: pK1 3.6, pK2 7.7
Absorption maximum: uv max (water): 260, 220 nm (E1% 18.9, 17.1)
Toxicity data: LD50 i.v. in mice: 330 mg/kg (Oestergaard)
Therap-Cat: Diuretic.
Keywords: Diuretic; Sulfonamide Derivatives.