Title: Sevoflurane
CAS Registry Number: 28523-86-6
CAS Name: 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane
Synonyms: fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether; fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether
Trademarks: Sevofrane (Maruishi); Sevorane (Abbott)
Molecular Formula: C4H3F7O
Molecular Weight: 200.05
Percent Composition: C 24.02%, H 1.51%, F 66.48%, O 8.00%
Line Formula: (CF3)2CHOCH2F
Literature References: Prepn: B. M. Regan, J. C. Longstreet,
DE 1954268;
eidem, US 3689571 (1970, 1972 both to Baxter Labs.). Pharmacology and physicochemical properties: R. F. Wallin
et al., Anesth. Analg. 54, 758 (1975). Clinical pharmacology and metabolism: D. A. Holaday, F. R. Smith,
Anesthesiology 54, 100 (1981). Toxicity study: D. P. Strum
et al., Anesth. Analg. 66, 769 (1987). Minimum alveolar concentration (MAC) in man: T. Katoh, K. Ikeda,
Anesthesiology 66, 301 (1987). Preliminary clinical evaluation in pheochromocytoma: M. Doi, K. Ikeda,
ibid. 70, 360 (1989).
Properties: Volatile liquid, bp751 58.1-58.2°; bp760 58.5°. d423 1.505. Vapor pressure (25°): 200 torr; (20°): 160 torr. Nonflammable in air at ambient temps; flammability limit in O2: 11 vol. percent; in N2O: 10 vol. percent. Partition coefficient at 37° (blood/gas): 0.60±0.07; (water/gas): 0.36±0.01; (corn oil/gas): 41.6±2.1.
Boiling point: bp751 58.1-58.2°; bp760 58.5°
Log P: Partition coefficient at 37° (blood/gas): 0.60±0.07; (water/gas): 0.36±0.01; (corn oil/gas): 41.6±2.1
Density: d423 1.505
Therap-Cat: Anesthetic (inhalation).
Keywords: Anesthetic (Inhalation).
