Home > Name List By 7 > 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine

CAS No 2898-12-6 , 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine

  • Name: 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine
  • Synonyms: Enobrin; Rudotel; Resmit;7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine; Ansilan; Azepamide; Lerisum; Medaurin; Aensius;Nobrium;
  • CAS Registry Number:
  • Transport: 3249
  • Flash Point: 198.4°C
  • Boiling Point: 404.4°Cat760mmHg
  • Density: 1.18g/cm3
  • Safety Statements: Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. A tranquilizer. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also DIAZEPAM.
  • Flash Point: 198.4°C
  • EINECS: 220-783-4
  • Molecular Weight: 270.7567
  • InchiKey: YLCXGBZIZBEVPZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H15ClN2/c1-19-10-9-18-16(12-5-3-2-4-6-12)14-11-13(17)7-8-15
    (14)19/h2-8,11H,9-10H2,1H3
  • Molecular Formula: C16H15ClN2
  • Molecular Structure:CAS No:2898-12-6 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine
References of 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1,4-benzodiazepine
Title: Medazepam
CAS Registry Number: 2898-12-6
CAS Name: 7-Chloro-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine
Trademarks: Ansilan (Lek); Diepin (Alcon); Medazepol (Farmasa); Megasedan (DIF); Narsis (Sumitomo); Nobrium (Roche); Psiquium (Sintofarma); Resmit (Shionogi); Rudotel (OPW); Tranquilax (Hokuriku)
Molecular Formula: C16H15ClN2
Molecular Weight: 270.76
Percent Composition: C 70.97%, H 5.58%, Cl 13.09%, N 10.35%
Literature References: Prepn: L. H. Sternbach et al., J. Org. Chem. 28, 2456 (1963); G. A. Archer et al., BE 620773 C.A. 59, 10095b (1963); E. Reeder, L. H. Sternbach, US 3243427 (1963, 1966 both to Hoffmann-La Roche); S. Inaba et al., Chem. Pharm. Bull. 20, 1628 (1972); M. Mihalic et al., J. Heterocycl. Chem. 14, 941 (1977). Pharmacology: L. O. Randall et al., Arch. Int. Pharmacodyn. Ther. 185, 135 (1970). Crystal structure: G. Gilli et al., Acta Crystallogr. B34, 3793 (1978).
Properties: Colorless prismatic crystals from ether + petr ether, mp 95-97°. LD50 in mice (mg/kg): 360 i.p., 1070 orally (Randall).
Melting point: mp 95-97°
Toxicity data: LD50 in mice (mg/kg): 360 i.p., 1070 orally (Randall)
 
Derivative Type: Hydrochloride
CAS Registry Number: 2898-11-5
Molecular Formula: C16H15ClN2.HCl
Molecular Weight: 307.22
Percent Composition: C 62.55%, H 5.25%, Cl 23.08%, N 9.12%
Properties: Orange-red crystalline powder. Freely sol in water, alcohol.
 
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.