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CAS No 2919-66-6 , Melengestrol acetate

  • Name: Melengestrol acetate
  • Synonyms: 17a-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione;Melengestrol acetate;
  • CAS Registry Number:
  • Melting Point: 202-204 ºC
  • Flash Point: 221.7°C
  • Boiling Point: 516.1°Cat760mmHg
  • Density: 1.15g/cm3
  • Refractive index: 1.554
  • Safety Statements: R62
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 221.7°C
  • EINECS: 220-859-7
  • Molecular Weight: 396.52
  • InChI: InChI=1/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1
  • Risk Statements: S36
  • Molecular Formula: C25H32O4
  • Molecular Structure:CAS No:2919-66-6 Melengestrol acetate

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References of Melengestrol acetate
Title: Melengestrol Acetate
CAS Registry Number: 2919-66-6
CAS Name: 17-(Acetyloxy)-6-methyl-16-methylenepregna-4,6-diene-3,20-dione
Synonyms: 6a-methyl-6-dehydro-16-methylene-17-acetoxyprogesterone
Trademarks: MGA (Pharmacia & Upjohn)
Molecular Formula: C25H32O4
Molecular Weight: 396.52
Percent Composition: C 75.73%, H 8.13%, O 16.14%
Literature References: Orally active progestational steroid. Prepn: D. N. Kirk et al., GB 886619; eidem, US 3332940 (1962, 1967 both to British Drug Houses). Environmental degradation study: B. Schiffer et al., Environ. Health Perspect. 109, 1145 (2001). Receptor binding study: G. A. Perry et al., Domest. Anim. Endocrinol. 28, 147 (2005). Review of pharmacology in animals: R. G. Zimbelman et al., J. Am. Vet. Med. Assoc. 157, 1528-1536 (1970); of use in control of bovine estrus: D. J. Patterson et al., J. Anim. Sci. 67, 1895-1906 (1989).
Properties: Needles from acetone/hexane, mp 224-226°. [a]D23 -127° (c = 0.31 in chloroform). uv max (ethanol): 287.5 nm (log e 4.35). LD50 (mg/kg): >8000 orally in rats; >2500 i.p. in mice (Zimbelman).
Melting point: mp 224-226°
Optical Rotation: [a]D23 -127° (c = 0.31 in chloroform)
Absorption maximum: uv max (ethanol): 287.5 nm (log e 4.35)
Toxicity data: LD50 (mg/kg): >8000 orally in rats; >2500 i.p. in mice (Zimbelman)
Therap-Cat-Vet: Progestogen; growth promotant.