Home > Name List By 2 > 2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2- methylbutanoic acid

CAS No 30299-08-2 , 2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-
methylbutanoic acid

  • Name: 2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-
    methylbutanoic acid
  • Synonyms: Clinofibrate [INN:JAN]; Lipoclin; Clinofibratum [INN-Latin]; 30299-08-2; Clinofibrato [INN-Spanish]; S 8527;2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-
    methylbutanoic acid;Lipoclin;
  • CAS Registry Number:
  • Density: 1.163 g/cm3
  • Refractive index: 1.558
  • Safety Statements: Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and fumes.
  • Molecular Weight: 468.58184
  • InchiKey: BMOVQUBVGICXQN-UHFFFAOYSA-N
  • InChI: InChI=1S/C28H36O6/c1-5-26(3,
    24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)
    34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)
  • Molecular Formula: C28H36O6
  • Molecular Structure:CAS No:30299-08-2 2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-<br />methylbutanoic acid

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References of 2-[4-[1-[4-(2-carboxybutan-2-yloxy)phenyl]cyclohexyl]phenoxy]-2-
methylbutanoic acid
Title: Clinofibrate
CAS Registry Number: 30299-08-2
CAS Name: 2,2￠-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methylbutanoic acid]
Synonyms: 2,2￠-(4,4￠-cyclohexylidenediphenoxy)-2,2￠-dimethyldibutyric acid
Manufacturers' Codes: S-8527
Trademarks: Lipoclin (Sumitomo)
Molecular Formula: C28H36O6
Molecular Weight: 468.58
Percent Composition: C 71.77%, H 7.74%, O 20.49%
Literature References: Anti-atherosclerosis agent, related structurally to clofibrate, q.v. Prepn: Y. Nakamura et al., DE 2017331; eidem, US 3716583 (1970, 1973 both to Sumitomo). Hypolipidemic activity: K. Toki et al., Atherosclerosis 18, 101 (1973); K. Suzuki et al., Jpn. J. Pharmacol. 24, 407 (1974), C.A. 82, 25821z (1975). Effect on cholesterol and lipoprotein metabolism in rats: K. Suzuki, Biochem. Pharmacol. 25, 325 (1976). General pharmacology: H. Nakatani et al., Oyo Yakuri 16, 687 (1978), C.A. 90, 145808 (1979).
Properties: Off-white powder, mp 143-146° (dec). Sol in methanol, ethanol, acetone, chloroform, glacial acetic acid. Slightly sol in CCl4. Practically insol in water.
Melting point: mp 143-146° (dec)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.