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CAS No 303-47-9 , L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanineAlanine,N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-(8CI)L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine NSC 221991

  • Name: L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanineAlanine,N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-(8CI)L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine NSC 221991
  • Synonyms: L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanineAlanine,N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-(8CI)L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine NSC 221991;L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanineAlanine,N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-(8CI)L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine; Phe-OTA;NSC 201422;L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanineAlanine,N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-(8CI);L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-; Ochratoxin A (7CI); L-Phenylalanine,N-[(5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-,(R)-; Phenylalanine-ochratoxin A;
  • CAS Registry Number:
  • Transport: UN 3462 6
  • Melting Point: 169°C
  • Density: 1.425 g/cm3
  • Water Solubility: ethanol: soluble
  • Safety Statements: 53-22-36/37/39-45-36-26-16-36/37-28-62
  • Hazard Symbols: T: Toxic;T+: Very toxic;Xn: Harmful;F: Flammable;
  • EINECS: 206-143-7
  • Molecular Weight: 403.81
  • InChI: InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
  • Risk Statements: 45-46-61-26/27/28-36-20/21/22-11-40-28-39/23/24/25-23/24/25-65-48/23/24/25-36/38
  • Molecular Formula: C20H18ClNO6
  • Molecular Structure:CAS No:303-47-9 L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanineAlanine,N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-(8CI)L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine NSC 221991
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303-47-9 Ochratoxin A Standard

  • Long term storage:+4°C.Protect from light. Naturally occuring mycotoxin produced by many species of Aspergillus. Ochratoxin A is potentially carcinogenic to humans (Group 2B). Ochratoxin A has been shown to be weakly mutagenic, possibly by induction ...
  • China Pribolab Biotech co., Ltd. [Manufacturer, Trading Company]
  • Tel: 86-0532-68069176
  • Fax: 86-0532-68069174
  • Address: Qingdao Hechuan Rd.35 Qingdao,ShandongChina
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303-47-9 OCHRATOXIN A

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany ,Germany
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303-47-9 OCBRATOXIN A

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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303-47-9 OCHRATOXIN A

  • Norway Chiron AS [Manufacturer]
  • Tel: +47 73 87 44 90
  • Fax: +47 73 87 44 99
  • Address: Chiron AS
    Stiklestadveien 1
    N-7041 Trondheim
    Norway ,Norway
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303-47-9 2231.20-10-5AN OCHRATOXIN A

  • Germany Campro Scientific GmbH [Manufacturer]
  • Tel: +49.(0)30.629.01.89.0 (Germany)/ +31.(0)318.529.437 (Netherlands)
  • Fax: +49.(0)30.629.01.89.89
    +31.(0)318.542.181
  • Address: Campro Scientific GmbH
    Postfach 36 20 65
    D-10972 Berlin
    Germany
    Tel. +49.(0)30.629.01.89.0
    Fax +49.(0)30.629.01.89.89
    info@campro.eu ,Germany
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303-47-9 OCHRATOXIN A

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany ,Germany
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303-47-9 OCHRATOXIN A

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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303-47-9 OCHRATOXIN A(RG)

  • United States ChromaDex Inc. [Manufacturer]
  • Tel: 949-419-0288
  • Fax: 949-419-0294
  • Address: ChromaDex Inc.
    10005 Muirlands Blvd. Suite G - First Floor
    Irvine, CA 92618 ,United States
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303-47-9 L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-

  • United States LKT Laboratories Inc. []
  • Tel: +1 888-558-5227
  • Fax: +1-(651)-644-8424
  • Address: Toll free 888-LKT-LABS St. Paul,United States
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303-47-9 OCHRATOXIN A

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland ,Switzerland
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References of L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanineAlanine,N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-(8CI)L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-Phenylalanine,N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-(R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo[c]pyran-7-yl)carbonyl]-3-phenylalanine NSC 221991
Title: Ochratoxins
Literature References: Toxic metabolites from Aspergillus ochraceus Wilh.: Scott, Mycopathol. Mycol. Appl. 25, 213 (1965); A. sulphureus and A. melleus: Lai et al., Appl. Microbiol. 19, 542 (1970); and Penicillium viridicatum Westling: van Walbeek et al., Can. J. Microbiol. 15, 1281 (1969). As these molds occur widely, some toxins have been found as natural contaminants on corn, peanuts, storage grains, cottonseed and other decaying vegetation. Isolns: van Walbeek et al., ibid. 14, 131 (1968); Shotwell et al., Appl. Microbiol. 17, 765 (1969); Nesheim, J. Assoc. Off. Anal. Chem. 52, 975 (1969); Natori et al., Chem. Pharm. Bull. 18, 2259 (1970). Structure and stereochemistry: van der Merwe et al., J. Chem. Soc. 1965, 7083; Nature 205, 1112 (1965). Synthesis of ochratoxins A, B and ester deriv: Steyn, Holzapfel, Tetrahedron 23, 4449 (1967); Nesheim, loc. cit.; Roberts, Woolven, J. Chem. Soc. C 1970, 278. Facile synthesis of A: G. A. Kraus, J. Org. Chem. 46, 201 (1981). Toxicity study: Purchase, Theron, Food Cosmet. Toxicol. 6, 479 (1968). Physicochemical data: A. E. Pohland et al., Pure Appl. Chem. 54, 2220 (1982). Comprehensive reviews: Steyn, "Ochratoxin and other Dihydroisocoumarins" in Microbial Toxins vol. VI, A. Ciegler, et al., Eds. (Academic Press, New York, 1971) p 179-205; F. S. Chu, Crit. Rev. Toxicol. 2, 499-524 (1974); P. Krogh in Natural Toxins, D. Eaker, P. Wadstr?m, Eds. (Pergamon, New York, 1980) pp 673-680; A. E. Pohland et al., Pure Appl. Chem. 64, 1029-1046 (1992).
 
Derivative Type: Ochratoxin A
CAS Registry Number: 303-47-9
CAS Name: (R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-L-phenylalanine
Molecular Formula: C20H18ClNO6
Molecular Weight: 403.81
Percent Composition: C 59.49%, H 4.49%, Cl 8.78%, N 3.47%, O 23.77%
Properties: The major ochratoxin component. Crystals from xylene, mp 169°. Exhibits green fluorescence. [a]D -118° (c = 1.1 in CHCl3). uv max (ethanol): 215, 333 nm (e 34000; 2400) (van der Merwe). Also frequently reported as mp 90° from benzene (one mole of benzene of crystallization). uv max: 213, 332 nm (e 36800; 6400) (Steyn, Holzapfel). LD50 orally in rats: 20-22 mg/kg (Purchase, Theron).
Melting point: mp 169°; mp 90° from benzene (one mole of benzene of crystallization)
Optical Rotation: [a]D -118° (c = 1.1 in CHCl3)
Absorption maximum: uv max (ethanol): 215, 333 nm (e 34000; 2400) (van der Merwe); uv max: 213, 332 nm (e 36800; 6400) (Steyn, Holzapfel)
Toxicity data: LD50 orally in rats: 20-22 mg/kg (Purchase, Theron)
 
Derivative Type: Ochratoxin B
CAS Registry Number: 4825-86-9
CAS Name: (R)-N-[(3,4-Dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-L-phenylalanine
Molecular Formula: C20H19NO6
Molecular Weight: 369.37
Percent Composition: C 65.03%, H 5.18%, N 3.79%, O 25.99%
Properties: The less toxic dechloro deriv of ochratoxin A. Crystals from methanol, mp 221° (van der Merwe); also reported as 208-209° (Nesheim). Exhibits blue fluorescence. [a]D -35° (c = 0.15 in ethanol). uv max: 218, 318 nm (e 37200, 6900).
Melting point: mp 221° (van der Merwe)
Optical Rotation: [a]D -35° (c = 0.15 in ethanol)
Absorption maximum: uv max: 218, 318 nm (e 37200, 6900)
 
Derivative Type: Ochratoxin C
CAS Registry Number: 4865-85-4
CAS Name: (R)-N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-L-phenylalanine ethyl ester
Molecular Formula: C22H22ClNO6
Molecular Weight: 431.87
Percent Composition: C 61.18%, H 5.13%, Cl 8.21%, N 3.24%, O 22.23%
Properties: The equally toxic amorphous ethyl ester of ochratoxin A: Steyn, Holzapfel, J. S. Afr. Chem. Inst. 20, 186 (1967), C.A. 69, 2797p (1968). uv max (ethanol): 333 nm (e 6500).
Absorption maximum: uv max (ethanol): 333 nm (e 6500)
 
CAUTION: Ochratoxin A is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-209.
Use: Exptlly as teratogen and carcinogen.