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CAS No 309-29-5 , 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one

  • Name: 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one
  • Synonyms: Doxapramum; Doxapram HCL; Doxapram [USP:JAN]; Doxapramum [INN-Latin]; 309-29-5;1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one; Docatone (TN);Dopram; Doxapram (INN);
  • CAS Registry Number:
  • Flash Point: 278.2 ºC
  • Boiling Point: 536.4 ºC at 760 mmHg
  • Density: 1.104 g/cm3
  • Refractive index: 1.562
  • Safety Statements: Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 278.2 ºC
  • EINECS: 206-216-3
  • Molecular Weight: 378.5072
  • InchiKey: XFDJYSQDBULQSI-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)
    27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3
  • Molecular Formula: C24H30N2O2
  • Molecular Structure:CAS No:309-29-5 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one

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References of 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one
Title: Doxapram
CAS Registry Number: 309-29-5
CAS Name: 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone
Molecular Formula: C24H30N2O2
Molecular Weight: 378.51
Percent Composition: C 76.16%, H 7.99%, N 7.40%, O 8.45%
Literature References: Prepn: C. D. Lunsford, A. D. Cale, BE 613734; eidem, US 3192206 (1962, 1965 both to A. H. Robins); Lunsford et al., J. Med. Chem. 7, 302 (1964). Clinical comparison with mepixanox in chronic bronchopulmonary disease: M. Parziale et al., G. Ital. Mal. Torace 38, 323 (1984). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
 
Derivative Type: Hydrochloride monohydrate
CAS Registry Number: 7081-53-0
Manufacturers' Codes: AHR-619
Trademarks: Dopram (Robins); Doxapril (Erba); Stimulexin (Robins)
Molecular Formula: C24H30N2O2.HCl.H2O
Molecular Weight: 432.98
Percent Composition: C 66.58%, H 7.68%, N 6.47%, O 11.09%, Cl 8.19%
Properties: Crystals from isopropyl ether, mp 217-219°. Bitter taste. Sol in water; sparingly sol in alc, slightly sol in chloroform. LD50 orally in rats: 261 mg/kg (Goldenthal).
Melting point: mp 217-219°
Toxicity data: LD50 orally in rats: 261 mg/kg (Goldenthal)
 
Derivative Type: Benzoate
Molecular Formula: C31H36N2O4
Molecular Weight: 500.63
Percent Composition: C 74.37%, H 7.25%, N 5.60%, O 12.78%
Properties: Crystals, mp 123-124°.
Melting point: mp 123-124°
 
Therap-Cat: Respiratory stimulant.
Therap-Cat-Vet: Respiratory stimulant.
Keywords: Respiratory Stimulant.