Title: Ishikawa Reagent
CAS Registry Number: 309-88-6
CAS Name: N,
N-Diethyl-1,1,2,3,3,3-hexafluoro-1-propanamine
Synonyms: PPDA
Molecular Formula: C7H11F6N
Molecular Weight: 223.16
Percent Composition: C 37.67%, H 4.97%, F 51.08%, N 6.28%
Literature References: Reagent for the fluorination of alcohols and esters; prepd from perfluoropropene and diethylamine. Prepn: I. L. Knunyants
et al., Bull. Acad. Sci. USSR Div. Chem. Sci. 1953, 255; D. C. England
et al., J. Am. Chem. Soc. 82, 5116 (1960); A. Y. Yakubovich
et al., Dokl. Akad. Nauk SSSR (Engl. Transl.) 161, 399 (1965); and use as a fluorinating agent: A. Takaoka
et al., Bull. Chem. Soc. Jpn. 52, 3377 (1979). Synthetic applications: S. Watanabe
et al., J. Fluorine Chem. 31, 135, 247 (1986);
36, 361 (1987);
38, 243 (1988);
39, 17 (1988);
47, 187 (1990); K. Ogu
et al., Tetrahedron Lett. 39, 305 (1998); G. Koch
et al., Synlett 2004, 693.
Properties: bp50 54° (England). Also reported as bp20 38-39° (Yakubovich).
nD24 1.2160. d424 1.2127.
Boiling point: bp50 54° (England); bp20 38-39° (Yakubovich)
Index of refraction: nD24 1.2160
Density: d424 1.2127
Use: Fluorinating agent.
