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CAS No 3093-35-4 , Halcinonide

  • Name: Halcinonide
  • Synonyms: Betacorton; DSSTox_CID_25375; 3093-35-4;Halcinonide; SQ 18566; Halciderm; Halcimat; Alcinonide; DSSTox_RID_80836;Halog;
  • CAS Registry Number:
  • Density: 1.31 g/cm3
  • Refractive index: 1.566
  • Safety Statements: R63
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 221-439-6
  • Molecular Weight: 454.959283
  • InchiKey: MUQNGPZZQDCDFT-JNQJZLCISA-N
  • InChI: InChI=1S/C24H32ClFO5/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,
    3)23(15,26)17(28)11-22(16,4)24(19,31-20)18(29)12-25/h9,15-17,19,28H,5-8,
    10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1
  • Risk Statements: S36
  • Molecular Formula: C24H32ClFO5
  • Molecular Structure:CAS No:3093-35-4 Halcinonide

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References of Halcinonide
Title: Halcinonide
CAS Registry Number: 3093-35-4
CAS Name: (11b,16a)-21-Chloro-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
Synonyms: 21-chloro-9-fluoro-11b,16a,17-trihydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal with acetone; 21-chloro-9a-fluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-4-pregnene-3,20-dione; 9a-fluoro-21-chloro-11b,16a,17a-trihydroxypregn-4-ene-3,20-dione 16,17-acetonide
Manufacturers' Codes: SQ-18566
Trademarks: Halciderm (BMS); Halcimat (BMS); Halog (BMS)
Molecular Formula: C24H32ClFO5
Molecular Weight: 454.96
Percent Composition: C 63.36%, H 7.09%, Cl 7.79%, F 4.18%, O 17.58%
Literature References: Prepn: Bernstein et al., J. Org. Chem. 27, 690 (1962); L. T. Difazio, M. A. Augustine, DE 2355710; eidem, US 3892857 (1972, 1975 both to Squibb). Pharmacological evaluation: Bagatell, Augustine, Curr. Ther. Res. 16, 748 (1974); R. C. Millonig, E. Yiakas, in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharmaceut. Assoc., Washington, DC, 1977) pp 215-231. Comprehensive description: J. Kirshbaum, Anal. Profiles Drug Subs. 8, 251-281 (1979).
Properties: Crystals from acetone-petr ether, mp 264-265° (dec). uv max (methanol): 238 nm (e 16400). [a]D25 +155° (CHCl3). Sol in acetone, chloroform, DMSO. Slightly sol in benzene, ethanol, ethyl ether, methanol. Insol in water, 0.1M HCl, 0.1M NaOH, hexanes. LD50 i.p. in mice: 150 mg/kg (Millonig, Yiakas).
Melting point: mp 264-265° (dec)
Optical Rotation: [a]D25 +155° (CHCl3)
Absorption maximum: uv max (methanol): 238 nm (e 16400)
Toxicity data: LD50 i.p. in mice: 150 mg/kg (Millonig, Yiakas)
Therap-Cat: Anti-inflammatory (topical).
Keywords: Glucocorticoid.