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CAS No 31112-62-6 , D-Glucose,2-[[3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy- Search by region : Germany

  • Name: D-Glucose,2-[[3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-
  • Synonyms: Metrizamide;D-Glucose,2-[3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido]-2-deoxy- (8CI);D-Glucose,2-[[3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-;Amipaque; Telebrix 300;
  • CAS Registry Number:
  • Melting Point: 222-224 ºC
  • Density: 2.35 g/cm3
  • Refractive index: 1.761
  • Water Solubility: Soluble in water
  • Safety Statements: 22-24/25
  • EINECS: 250-475-5
  • Molecular Weight: 789.13
  • InChI: InChI=1S/C18H22I3N3O8/c1-5(26)22-12-9(19)8(10(20)14(11(12)21)24(3)6(2)27)17(30)23-13-16(29)15(28)7(4-25)32-18(13)31/h7,13,15-16,18,25,28-29,31H,4H2,1-3H3,(H,22,26)(H,23,30)/t7?,13?,15-,16?,18+/m1/s1
  • Molecular Formula: C18H22 I3 N3 O8
  • Molecular Structure:CAS No:31112-62-6 D-Glucose,2-[[3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-

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31112-62-6 METRIZAMIDE,P.A.

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
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    Germany null,nullGermany
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References of D-Glucose,2-[[3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-
Title: Metrizamide
CAS Registry Number: 31112-62-6
CAS Name: 2-[[3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-D-glucose
Synonyms: 2-[3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido]-2-deoxy-D-glucose; 2-[3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido]-2-deoxy-D-glucopyranose
Manufacturers' Codes: Win-39103
Trademarks: Amipaque (Winthrop)
Molecular Formula: C18H22I3N3O8
Molecular Weight: 789.10
Percent Composition: C 27.40%, H 2.81%, I 48.25%, N 5.33%, O 16.22%
Literature References: X-ray contrast agent related to metrizoic acid, q.v. Prepn: H. O. Torsten et al., DE 2031724; eidem, US 3701771 (1971, 1972 both to Nyegaard). Metabolism: J. G. Johansen, S. Kolmannskog, Invest. Radiol. 13, 93 (1978). Pharmacology: T. W. Morris et al., ibid. 74; G. F. Dibona, Proc. Soc. Exp. Biol. Med. 157, 453 (1978). Series of articles on clinical use: Ann. Radiol. 22, 195-206 (1979). Toxicity studies: S. Salvesen, Radiology 123, 241 (1977); M. Sovak et al., ibid. 242; P. Aspelin, Invest. Radiol. 11, 309 (1976). Review: L. Hol et al., in Pharmacological and Biochemical Properties of Drug Substances vol. 1, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1977) pp 387-412.
Properties: White crystals from isopropyl alcohol, mp 230° (dec), after drying in vacuo at room temp and 70°. [a]D20 +18.0° (c = 10% in 0.1N HCl; equilibrated with respect to mutarotation). Very sol in water (50% w/v) at room temp. LD50 i.v. in mice: 15 g/kg (Torsten); 18.6 g/kg (Salveson); 11.5 g/kg (Sovak); 17.3 g/kg (Aspelin).
Melting point: mp 230° (dec)
Optical Rotation: [a]D20 +18.0° (c = 10% in 0.1N HCl; equilibrated with respect to mutarotation)
Toxicity data: LD50 i.v. in mice: 15 g/kg (Torsten); 18.6 g/kg (Salveson); 11.5 g/kg (Sovak); 17.3 g/kg (Aspelin)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium).