Home > Name List By 5 > 5-Azacytidine

CAS No 320-67-2 , 5-Azacytidine

  • Name: 5-Azacytidine
  • Synonyms: 4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one; 5-AC; 5-AZCR;4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; nci-c01569; Azacitidine; Azacytidine; 5-AZAC;5-Azacytidine; wr 183027; ladakamycin; 4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; antibioticu18496; 4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one; u18496; 4-amino-1-beta-d-ribofuranosyl-s-triazin-2(1h)-on; 5 AZC; nsc-102816; mylosar; u 18496; Antibiotic u 18496; 5-triazin-2(1h)-one,4-amino-1-beta-d-ribofuranosyl-3;
  • CAS Registry Number:
  • Melting Point: 228-230 ºC
  • Flash Point: 277 ºC
  • Boiling Point: 534.5 ºC at 760 mmHg
  • Density: 2.08 g/cm3
  • Refractive index: 1.823
  • Alpha: 40 º (C=1, H2O 22 ºC)
  • Water Solubility: 0.5-1.0 G/100 ML AT 21 ºC
  • Safety Statements: R45;R46;R22
  • Hazard Symbols: T: Toxic;
  • Flash Point: 277 ºC
  • EINECS: 206-280-2
  • Molecular Weight: 244.21
  • InChI: InChI=1/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
  • Risk Statements: S53;S22;S36/37/39;S45
  • Molecular Formula: C8H12N4O5
  • Molecular Structure:CAS No:320-67-2 5-Azacytidine

Related products

Search by region :

Select to

320-67-2 5-Azacytidine

  • China Melone Pharmaceutical Co., ltd [Manufacturers]
  • Tel: +86-411 82593920, 82593631
  • Fax: +86-411-82593613
  • Address: No 232, JInma Roda, Development Zone, Dalian, China null,Liao NingChina
Contact Supplier

320-67-2 5-Azacytidine

  • China Shanghai GLSynthesis Co. Ltd [Manufacturers]
  • Tel: 0512-58327205(销售) 58327210
  • Fax: 0512-58327205
  • Address: YangZi River Chemical Industrial Park,2 HuaDa Road Zhangjiagang, 215600 China Zhangjiagang,shanghaiChina
Contact Supplier

320-67-2 Azacitidine

  • China Porton Corporation null
  • Tel: 023 67038621 02367038639
  • Fax: 86-23-6703 8513
  • Address: Building 6, Sunteam Office Park, 18 West Honghu Road, Yubei District, Chongqing, 401121, China. null,nullChina
Contact Supplier

320-67-2 5-Azacytidine

  • China Hangzhou Hysen Pharma [Importer/Exporter]
  • Tel: +86-571-89937383
  • Fax: +86-571-89937383
  • Address: No.808, B Building,Zijin Plaza, No.701,Gudun ROAD,Hangzhou CHINA-310012 HANGZHOU,ZHEJIANGChina
Contact Supplier

320-67-2 5-Azacytidine

Contact Supplier

320-67-2 5-Azacytidine

  • Germany Pharma Waldhof GmbH [Manufacturer]
  • Tel: +49 (0)211 - 52 60 23/ +49 (0)211 - 52 60 20
  • Fax: +49 (0)211 - 52 60 222
  • Address: Pharma Waldhof GmbH
    Hansaallee 159 D-40549 D?sseldorf
    Germany null,nullGermany
Contact Supplier

320-67-2 5-Azacytidine

Contact Supplier

320-67-2 5-Azacytidine

Contact Supplier

320-67-2 5-Azacytidine

  • China Shanghai Meg Import & Export Co., Ltd [Manufacturers]
  • Tel: +86-21-51082199
  • Fax: 86-21-50276058
  • Address: 4-101 NO.299 Bisheng Road, Zhangjiang Hi-Tech Park, Shanghai, 201204, China Shanghai,ShanghaiChina
Contact Supplier

320-67-2 5-Azacytidine

Contact Supplier

Select to

7/9
Previous 1 2 3 4 5 6 7 8 9 Next
References of 5-Azacytidine
Title: Azacitidine
CAS Registry Number: 320-67-2
CAS Name: 4-Amino-1-b-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Synonyms: 5-azacytidine; 5-AzaC; ladakamycin
Manufacturers' Codes: U-18496; NSC-102816
Trademarks: Mylosar (formerly); Vidaza (Pharmion)
Molecular Formula: C8H12N4O5
Molecular Weight: 244.20
Percent Composition: C 39.35%, H 4.95%, N 22.94%, O 32.76%
Literature References: DNA methylation inhibitor; analog of the pyrimidine nucleoside, cytidine, q.v. Chemical synthesis: A. Piskala, F. Sorm, Collect. Czech. Chem. Commun. 29, 2060 (1964); M. W. Winkley, R. K. Robins, J. Org. Chem. 35, 491 (1970). Production by fermentation of Streptoverticillium ladakanus and activity: L. J. Hanka et al., Antimicrob. Agents Chemother. 1966, 619; M. E. Bergy, R. R. Herr, ibid. 625. HPLC determn in pharmaceutical prepns: L. D. Kissinger, N. L. Stemm, J. Chromatogr. 353, 309 (1986). Toxicology study: P. E. Palm, C. J. Kensler, U.S. Clearinghouse Fed. Sci. Tech. Inform. (PB-194791, 1970) 191 pp., C.A. 75, 33704j (1971). Review of clinical experience in acute nonlymphocytic leukemia: A. B. Glover et al., Cancer Treat. Rep. 71, 737-746 (1987); of mechanism of action: A. B. Glover, B. Leyland-Jones, ibid. 959-964. Review of carcinogenic risk: IARC Monographs 50, 47-63 (1990). Clinical efficacy in b-thalassemia: C. H. Lowrey, A. W. Nienhuis, N. Engl. J. Med. 329, 845 (1993); in myelodysplastic syndrome: L. R. Silverman et al., J. Clin. Oncol. 20, 2429 (2002); A. B. Kornblith et al., ibid. 2441.
Properties: Crystals from aq ethanol, mp 235-237° (dec). [a]D26 +22.4° (c = 1 in water). uv max (water): 241 nm (e 8767); (0.01N HCl): 249 nm (e 3077); (0.01N KOH): 223 nm (e 24200). Soly (mg/ml): 40 warm water, 14 cold water, 28 0.1N HCl, 43 0.1N NaOH, 52.7 DMSO, 1 acetone, 1 chloroform, 1 hexane. LD50 in mice (mg/kg): 115.9 i.p.; 572.3 orally (Palm, Kensler).
Melting point: mp 235-237° (dec)
Optical Rotation: [a]D26 +22.4° (c = 1 in water)
Absorption maximum: uv max (water): 241 nm (e 8767); (0.01N HCl): 249 nm (e 3077); (0.01N KOH): 223 nm (e 24200)
Toxicity data: LD50 in mice (mg/kg): 115.9 i.p.; 572.3 orally (Palm, Kensler)
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-24.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Pyrimidine Analogs.