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CAS No 32986-56-4 , Tobramycin Search by region : China

  • Name: Tobramycin
  • CAS Registry Number:
  • Density: 1.52 g/cm3
  • Refractive index: 143 ° (C=4, H2O)
  • Water Solubility: Very soluble in water
  • Safety Statements: S26;S37/39
  • Hazard Symbols: Xi: Irritant;
  • EINECS: 251-322-5
  • Molecular Weight: 467.51
  • InChI: InChI=1/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1
  • Risk Statements: R36/37/38
  • Molecular Formula: C18H37N5O9
  • Molecular Structure:CAS No:32986-56-4 Tobramycin

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References of Tobramycin
Title: Tobramycin
CAS Registry Number: 32986-56-4
CAS Name: O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1?6)-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribo-hexopyranosyl-(1?4)]-2-deoxy-D-streptamine
Synonyms: 4-[2,6-diamino-2,3,6-trideoxy-a-D-glycopyranosyl]-6-[3-amino-3-deoxy-a-D-glycopyranosyl]-2-deoxystreptamine; nebramycin factor 6; NF 6
Trademarks: Tobracin (Shionogi); Tobralex (Alcon); Tobramaxin (Alcon); Tobrex (Alcon)
Molecular Formula: C18H37N5O9
Molecular Weight: 467.51
Percent Composition: C 46.24%, H 7.98%, N 14.98%, O 30.80%
Literature References: Aminoglycoside antibiotic; component of the nebramycin complex produced by Streptomyces tenebrarius. See also apramycin. Series of articles on isolation, separation and evaluation of the nebramycin complex: Antimicrob. Agents Chemother. 1967, 314-348. Elucidation of structure: K. F. Koch, J. A. Rhoades, Antimicrob. Agents Chemother. 1970, 309. Synthesis: Y. Takagi et al., Bull. Chem. Soc. Jpn. 49, 3649 (1976); M. Tanabe et al., Tetrahedron Lett. 1977, 3607. Toxicology: J. S. Welles et al., Toxicol. Appl. Pharmacol. 22, 332 (1972). Comprehensive description: A. K. Dash, Anal. Profiles Drug Subs. Excip. 24, 579-613 (1996). Clinical trial in cystic fibrosis patients: B. W. Ramsey et al., N. Engl. J. Med. 340, 23 (1999). Review of clinical experience: H. Lode, Curr. Ther. Res. 59, 420-453 (1998).
Properties: Basic substance. Freely sol in water (1 in 1.5 parts). Very slightly sol in ethanol (1 in 2000 parts). Practically insol in chloroform, ether. [a]D20 +129° (c = 1 in water). LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles).
Optical Rotation: [a]D20 +129° (c = 1 in water)
Toxicity data: LD50 in mice, rats (mg/kg): 441, 969 s.c. (Welles)
 
Derivative Type: Sulfate
CAS Registry Number: 79645-27-5
Trademarks: Gernebcin (Lilly); Nebcin (Lilly); Nebicina (Lilly); Obracin (Lilly); Tobra (Lilly); Tobradistin (Dista)
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Aminoglycosides.