Home > Name List By 1 > 1-[(2S,4R, 5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

CAS No 3424-98-4 , 1-[(2S,4R,
5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

  • Name: 1-[(2S,4R,
    5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
  • Synonyms: 2'-Deoxy-L-thymidine;1-[(2S,4R,
    5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Epavudine; Sebivo; beta-L-Thymidine; L-Deoxythymidine; Telbivudin;Tyzeka; L-Thymidine; L-dT;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.452 g/cm3
  • Refractive index: 1.584
  • Flash Point: °C
  • Molecular Weight: 242.22856
  • InchiKey: IQFYYKKMVGJFEH-CSMHCCOUSA-N
  • InChI: InChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,
    6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m1/s1
  • Molecular Formula: C10H14N2O5
  • Molecular Structure:CAS No:3424-98-4 1-[(2S,4R,<br />5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

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References of 1-[(2S,4R,
5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
Title: Telbivudine
CAS Registry Number: 3424-98-4
CAS Name: 1-(2-Deoxy-b-L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
Synonyms: 1,2￠-deoxy-b-L-ribofuranosylthymine; 2￠-deoxy-L-thymidine; LdT; L-thymidine
Molecular Formula: C10H14N2O5
Molecular Weight: 242.23
Percent Composition: C 49.58%, H 5.83%, N 11.56%, O 33.03%
Literature References: Nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Prepn: J. Smejkal, F. Sorm, Collect. Czech. Chem. Commun. 29, 2809 (1964); A. Holy, ibid. 37, 4072 (1972). Anti-HBV activity: M. L. Bryant et al., Nucleosides Nucleotides Nucleic Acids 20, 597 (2001). In vitro pharmacology: B. Hernandez-Santiago et al., Antimicrob. Agents Chemother. 46, 1728 (2002). Clinical evaluation in hepatitis B: C.-L. Lai et al., Hepatology 40, 719 (2004). Review of mechanism of action and pharmacology: D. N. Standring et al., Antiviral Chem. Chemother. 12, Suppl. 1, 119-129 (2001); of clinical development: S.-H. B. Han, Expert Opin. Invest. Drugs 14, 511-519 (2005). See also Thymidine.
Properties: Crystals from ethanol, mp 186°(Smejkal, Sorm). [a]D20 -20.3° (c = 0.192 in water). Also reported as mp 189° (Holy). uv max (pH 2): 267 nm (e 9800).
Melting point: mp 186°; mp 189°
Optical Rotation: [a]D20 -20.3° (c = 0.192 in water)
Absorption maximum: uv max (pH 2): 267 nm
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones.