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CAS No 357-57-3 , Brucine

  • Name: Brucine
  • Synonyms: Brucine;10,11-Dimethoxystrychnine;
  • CAS Registry Number:
  • Transport: UN 1570
  • Melting Point: 175-178 ºC (DEC.)
  • Density: 1.41 g/cm3
  • Refractive index: 1.685
  • Alpha: -118 º (C=2.5 IN CHLOROFORM)
  • Water Solubility: slight
  • Safety Statements: R26/28;R52/53
  • Hazard Symbols: T+: Very toxic;
  • EINECS: 206-614-7
  • Molecular Weight: 394.46
  • InChI: InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3
  • Risk Statements: S13;S45;S61
  • Molecular Formula: C23H26N2O4
  • Molecular Structure:CAS No:357-57-3 Brucine
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357-57-3 Brucine

  • Brucine
  • United States Chem-Impex International, Inc. [Manufacturer]
  • Tel: 630 766 2112
  • Fax: 630 766 2218
  • Address: 935 Dillon Drive Wood Dale IL 60191 USA ,United States
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357-57-3 Strychnidin-10-one,2,3-dimethoxy-

  • China Fast Pharm Co.,Ltd [Manufacturers]
  • Tel: 8602133538380
  • Fax: 86-021-32082820
  • Address: No.17#-6D. 830 Lane,Maotai Road Shanghai,SH200336,China Shanghai,ShanghaiChina
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357-57-3 Brucine

  • Brucine
  • Hong kong Frapp's Pharma (Hongkong) Co.,Ltd [Manufacturer]
  • Tel: +852 8130 0917
  • Fax: +852 8130 0927
  • Address: Room 801,Mongkok Harbour Centre,638 Shanghai Street,Mongkok,Kowloon,Hongkang518001 MongkokHONG KONG Mongkok,Hong kong
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357-57-3 Brucine

  • Brucine
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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357-57-3 Strychnidin-10-one,2,3-dimethoxy-

  • China Shanghai Hanhong Chemical Co., Ltd. [, Manufacturer, Trading Company, Agent]
  • Tel: +86-(21)-64762736, 64531573
  • Fax: +86-(21)-54291107
  • Address: 206-209, NO.1 Building , NO.245,Jiachuan Road, Xuhui District, Shanghai, Xuhui District,ShanghaiChina
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357-57-3 BRUCINE

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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357-57-3 Strychnidin-10-one,2,3-dimethoxy-

  • China SHANGHAI HANHONG CHEMICAL CO.,LTD. [Manufacturers]
  • Tel: 021-64545202
  • Fax: 021-54291107
  • Address: Room 207, Zenghe Building , No.245, Jiachuan Road, Xuhui District, Shanghai, China shanghai,shanghaiChina
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357-57-3 Brucine

  • Brucine
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
  • Fax: +86-023-67030809
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,China
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357-57-3 Brucine

  • Brucine
  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
  • Fax: +86-21-64968086
  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,China
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357-57-3 Strychnidin-10-one,2,3-dimethoxy-

  • China BINHAI HANHONG BIOCHEMICAL CO., LTD. [Manufacturers]
  • Tel: +86-21-54302127
  • Fax: +86-21-54291107
  • Address: Room 209,Zonghe Building ,Jiachuan Road 245, Xuhui District, Shanghai, China Shanghai,ShanghaiChina
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References of Brucine
Title: Brucine
CAS Registry Number: 357-57-3
CAS Name: 2,3-Dimethoxystrychnidin-10-one
Synonyms: 10,11-dimethoxystrychnine
Molecular Formula: C23H26N2O4
Molecular Weight: 394.46
Percent Composition: C 70.03%, H 6.64%, N 7.10%, O 16.22%
Literature References: Toxic alkaloid resembling strychnine. Isoln from Strychnos seeds (Strychnos nux-vomica L. and S. ignatii Berg., Loganiaceae): C. Hartwick, P. Geiger, Arch. Pharm. 239, 491 (1901). Prepn from strychnine, q.v.: E. Tedeschi et al., Tetrahedron 24, 4573 (1968). 13C-NMR study: E. Wenkert et al., J. Org. Chem. 43, 1099 (1978). Electrophoretic determn in seeds: Y.-Y. Zong, C. Che, Planta Med. 61, 456 (1995). Toxicity data: M. H. Malone et al., J. Ethnopharmacol. 35, 295 (1992). Use as reagent for sulfur compounds: M. K. Tummuru et al., Analyst 109, 1105 (1984); for nitrates: J. Masini et al., Anal. Chem. 69, 1077 (1997). Review of structural elucidation: H. L. Holmes, Elucidation of the Structure of Strychnine and Brucine in The Alkaloids vol. I, R. H. F. Manske, Ed. (Academic Press, New York, 1950) pp 377-420.
Properties: Needles from acetone + water, mp 178°. [a]D -127° (chloroform), -85° (in abs alcohol). uv max (ethanol): 263, 301 nm (log e 4.09, 3.93).
Melting point: mp 178°
Optical Rotation: [a]D -127° (chloroform), -85° (in abs alcohol)
Absorption maximum: uv max (ethanol): 263, 301 nm (log e 4.09, 3.93)
 
Derivative Type: Tetrahydrate
Properties: Monoclinic prisms. Also forms a dihydrate. Very bitter taste. Bitterness threshold 1:220,000. Very poisonous! Handle dry powder in hood only. Becomes anhydr at 100°. One gram dissolves in 0.8 ml methanol, 1.3 ml alcohol, 5 ml chloroform, 25 ml ethyl acetate, 36 ml glycerol, about 100 ml benzene, 187 ml ether, 1320 ml water, 750 ml boiling water. pH of satd water soln 9.5. pK1 6.04, pK2 11.7. LD50 in mice (mg/kg): 12.0 i.v.; 62.0 i.p.; 150.0 orally (Malone).
pKa: pK1 6.04, pK2 11.7
Toxicity data: LD50 in mice (mg/kg): 12.0 i.v.; 62.0 i.p.; 150.0 orally (Malone)
 
Use: Denaturing alcohol and oils; in analytical chemistry; for separating racemic mixtures. Addition agent to lubricants.
Therap-Cat: CNS stimulant.
Keywords: CNS Stimulant.