Home > Name List By 8 > 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7, 9-dione China

CAS No 36505-84-7 , 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,
9-dione Search by region : China

  • Name: 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,
    9-dione
  • Synonyms: Anxiron; Buspirona [INN-Spanish]; Buspisal;Ansial; Buspironum [INN-Latin]; Bespar; Buspironum; Ansiced;8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,
    9-dione; Buspirona;
  • CAS Registry Number:
  • Transport: UN 2811 6
  • Density: 1.24g/cm3
  • Safety Statements: Poison by intraperitoneal route. Human systemic effects by an unspecified route: change in motor activity. When heated to decomposition it emits toxic fumes of NOx. Used as an anxiolytic agent.
  • Hazard Symbols: T: Toxic;
  • EINECS: 253-072-2
  • Molecular Weight: 385.50314
  • InchiKey: QWCRAEMEVRGPNT-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-
    12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
  • Risk Statements: 25
  • Molecular Formula: C21H31N5O2
  • Molecular Structure:CAS No:36505-84-7 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,<br />9-dione

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36505-84-7 Buspirone

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China null,nullChina
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36505-84-7 8-Azaspiro[4.5]decane-7,9-dione,8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-

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36505-84-7 Buspirone hydrochloride

  • Buspirone hydrochloride
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
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36505-84-7 Buspirone hydrochloride

  • Buspirone hydrochloride, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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36505-84-7 Buspirone Hydrochloride

  • Buspirone Hydrochloride
  • China Betapharma Shanghai Inc.Co., Ltd [Manufacturer]
  • Tel: 86-21-62951620
  • Fax: 86-21-32230794
  • Address: Jinming Building 12A No. 8 Zunyi(S) Rd. Shanghai China 200336 shanghaiCHINA shanghai,nullChina
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36505-84-7 Buspirone HCl

  • Buspirone HClBuspirone HCl, 98%
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
  • Fax: +86-023-67030809
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,nullChina
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36505-84-7 Buspirone HCl

  • Buspirone HCl, 98%
  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
  • Fax: +86-21-64968086
  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,nullChina
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36505-84-7 Buspirone Hydrochloride

  • Buspirone Hydrochloride, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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36505-84-7 Buspirone

  • China Hangzhou Sage Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-571-86818502
  • Fax: +86-571-86818503
  • Address: RM501 Tower A, New Youth Plaza, NO.8 Jia Shan Road, Hangzhou, Zhejiang 310014, null,ZhejiangChina
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36505-84-7 Buspirone Hydrochloride

  • Buspirone Hydrochloride, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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References of 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,
9-dione
Title: Buspirone
CAS Registry Number: 36505-84-7
CAS Name: 8-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular Formula: C21H31N5O2
Molecular Weight: 385.50
Percent Composition: C 65.43%, H 8.11%, N 18.17%, O 8.30%
Literature References: Non-benzodiazepine anxiolytic; 5-hydroxytryptamine (5-HT1) receptor agonist. Prepn: Y. H. Wu et al., J. Med. Chem. 15, 477 (1972); Y. H. Wu, J. W. Rayburn, DE 2057845 (1971 to Bristol-Myers); eidem, US 3717634 (1973 to Mead-Johnson). Pharmacology: L. E. Allen et al., Arzneim.-Forsch. 24, 917 (1974). Comparison with diazepam in treatment of anxiety: H. L. Goldberg, R. J. Finnerty, Am. J. Psychiatry 136, 1184 (1979); A. F. Jacobson et al., Pharmacotherapy 5, 290 (1985). Nonsynergistic effect with alcohol: T. Seppala et al., Clin. Pharmacol. Ther. 32, 201 (1982). Disposition and metabolism: S. Caccia et al., Xenobiotica 13, 147 (1983). Series of articles on chemistry, pharmacology, addictive potential, and clinical trials: J. Clin. Psychiatry 43, pp 1-116 (1982); on pharmacology, safety and clinical comparison with clorazepate: Am. J. Med. 80, Suppl. 3B, 1-51 (1986). Review of pharmacology and therapeutic efficacy: K. L. Goa, A. Ward, Drugs 32, 114-129 (1986). Review: M. W. Jann, Pharmacotherapy 8, 100-116 (1988); D. P. Taylor, FASEB J. 2, 2445-2452 (1988).
 
Derivative Type: Hydrochloride
CAS Registry Number: 33386-08-2
Trademarks: Ansial (Vita); Ansiced (Abello); Axoren (Glaxo Wellcome); Bespar (BMS); Buspar (BMS); Buspimen (Menarini); Buspinol (Zdravlje); Buspisal (Lesvi); Narol (Almirall)
Molecular Formula: C21H31N5O2.HCl
Molecular Weight: 421.96
Percent Composition: C 59.77%, H 7.64%, N 16.60%, O 7.58%, Cl 8.40%
Properties: Crystals from abs ethanol, mp 201.5-202.5°. LD50 i.p. in rats: 136 mg/kg (Allen).
Melting point: mp 201.5-202.5°
Toxicity data: LD50 i.p. in rats: 136 mg/kg (Allen)
 
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Arylpiperazines; Serotonin Receptor Agonist.