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CAS No 37350-58-6 , 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

  • Name: 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
  • Synonyms: Lopresor; Lopresoretic; Betaloc;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol; Spesicor; Seloken;Lopressor; Presolol; Preblok; Beatrolol;
  • CAS Registry Number:
  • Density: 1.033 g/cm3
  • EINECS: 253-483-7
  • Molecular Weight: 267.3639
  • InchiKey: IUBSYMUCCVWXPE-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/
    h4-7,12,14,16-17H,8-11H2,1-3H3
  • Molecular Formula: C15H25NO3
  • Molecular Structure:CAS No:37350-58-6 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol

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37350-58-6; 51384-51-1 Betaloc

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37350-58-6 Metoprolol

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References of 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
Title: Metoprolol
CAS Registry Number: 37350-58-6
CAS Name: 1-[4-(2-Methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol
Synonyms: (±)-1-(isopropylamino)-3-[p-(b-methoxyethyl)phenoxy]-2-propanol
Manufacturers' Codes: CGP-2175; H-93/26
Molecular Formula: C15H25NO3
Molecular Weight: 267.36
Percent Composition: C 67.38%, H 9.42%, N 5.24%, O 17.95%
Literature References: b1-Adrenergic blocker lacking intrinsic sympathomimetic activity. Prepn: A. E. Brandstrom et al., DE 2106209; eidem, US 3998790 (1971, 1976 both to AB H?ssle). Pharmacology: B. Ablad et al., Life Sci. 12, 107 (1973); Johansson, Eur. J. Pharmacol. 24, 194 (1973). Toxicology: N.-O. Bodin et al., Acta Pharmacol. Toxicol. 36, Suppl. V, 96 (1975). Clinical trials in acute myocardial infarction: L. Rydén et al., N. Engl. J. Med. 308, 614 (1983); Drugs 29, Suppl. 1, 2-8 (1985); in chronic heart failure: A. Hjalmarson et al., J. Am. Med. Assoc. 283, 1295 (2000). Comprehensive description: J. R. Luch, Anal. Profiles Drug Subs. 12, 325-356 (1983). Review of pharmacology, therapeutic efficacy: P. Benfield et al., Drugs 31, 376-429 (1986).
 
Derivative Type: Succinate
CAS Registry Number: 98418-47-4
Trademarks: Selo-Zok (AstraZeneca); Toprol-XL (AstraZeneca)
Molecular Formula: (C15H25NO3)2.C4H6O4
Molecular Weight: 652.82
Percent Composition: C 62.55%, H 8.65%, N 4.29%, O 24.51%
 
Derivative Type: Tartrate
CAS Registry Number: 56392-17-7
Trademarks: Beloc (AstraZeneca); Betaloc (AstraZeneca); Lopressor (Novartis); Lopresor (Novartis); Prelis (Novartis); Seloken (AstraZeneca); Selopral (Orion)
Molecular Formula: (C15H25NO3)2.C4H6O6
Molecular Weight: 684.81
Percent Composition: C 59.63%, H 8.24%, N 4.09%, O 28.04%
Properties: Soly (mg/ml) at 25°: water >1000; methanol >500; chloroform 496; acetone 1.1; acetonitrile 0.89; hexane 0.001. uv max (water): 223 nm (e 23400). LD50 in female mice, male rats (mg/kg): 118, ~90 i.v.; 2090, 3090 orally (Bodin).
Absorption maximum: uv max (water): 223 nm (e 23400)
Toxicity data: LD50 in female mice, male rats (mg/kg): 118, ~90 i.v.; 2090, 3090 orally (Bodin)
 
Therap-Cat: Antihypertensive; antianginal; antiarrhythmic (class II).
Keywords: ?Adrenergic Blocker; Antianginal; Antihypertensive; Aryloxypropanolamine Derivatives.