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CAS No 37517-30-9 , N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide

  • Name: N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide
  • Synonyms: Acebutololum; dl-Acebutolol; Prent;Acetobutolol; Acebutolol HCL; Acebutololo;N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide; (+-)-Acebutolol; Neptal; Sectral;
  • CAS Registry Number:
  • Melting Point: 119-123 ºC
  • Flash Point: 295°C
  • Boiling Point: 564.1°C at 760 mmHg
  • Density: 1.118g/cm3
  • Refractive index: 1.542
  • Water Solubility: 259 MG/L
  • Safety Statements: Moderately toxic by intravenous route. Human systemic effects by ingestion: developmental abnormalities of the cardiovascular and respiratory systems; effects on newborn in biochemical and metabolic abnormalities and reduced growth statistics. A human teratogen. When heated to decomposition it emits toxic fumes of NOx. A beta-adrenergic blocker.
  • Flash Point: 295°C
  • EINECS: 253-539-0
  • Molecular Weight: 336.42592
  • InchiKey: GOEMGAFJFRBGGG-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H28N2O4/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15
    (22)10-19-12(2)3/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23)
  • Molecular Formula: C18H28N2O4
  • Molecular Structure:CAS No:37517-30-9 N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide
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37517-30-9 Acebutolol

  • IUPAC NAME-(RS)-N-{3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}butanamide MOLECULAR FORMULA-C18H28N2O4 MOLAR MASS-336.426 g/mol
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641870
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

37517-30-9 ACEBUTOLOL

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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37517-30-9 Acebutolol

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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37517-30-9 Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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37517-30-9 Acebutolol

  • China Haihang Industry Co., Ltd. []
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, ,China
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37517-30-9 Acebutolol

  • China China Langchem Inc. []
  • Tel: +86-(21)-58956006
  • Fax: +86-(21)-58956100
  • Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203, ,China
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37517-30-9 Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-

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37517-30-9 Acebutolol

  • India Manus Aktteva []
  • Tel: +91-(79)-65123395
  • Fax: +91-(79)-26463395
  • Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006, ,India
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37517-30-9 ACEBUTOLOL HYDROCHLORIDE

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland ,Switzerland
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37517-30-9 ACEBUTOLOL-D5

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. ,India
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References of N-[3-acetyl-4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]butanamide
Title: Acebutolol
CAS Registry Number: 37517-30-9
CAS Name: N-[3-Acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]butanamide
Synonyms: 3¢-acetyl-4¢-[2-hydroxy-3-(isopropylamino)propoxy]butyranilide; 1-(2-acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane; 5¢-butyramido-2¢-(2-hydroxy-3-isopropylaminopropoxy)acetophenone
Molecular Formula: C18H28N2O4
Molecular Weight: 336.43
Percent Composition: C 64.26%, H 8.39%, N 8.33%, O 19.02%
Literature References: Cardioselective b-adrenergic blocker. Prepn: K. R. H. Wooldridge, B. Basil, ZA 6808345; eidem, US 3857952 (1969, 1974 both to May & Baker). Pharmacology: Cuthbert, Owusu-Ankomah, Br. J. Pharmacol. 43, 639 (1971); Basil et al., ibid. 48, 198 (1973); Lewis et al., Br. Heart J. 35, 743 (1973). HPLC determn in plasma and urine: M. Piquette-Miller et al., J. Chromatogr. 526, 129 (1990). Crystal structure: A. Carpy et al., Acta Crystallogr. B35, 185 (1979). Review of pharmacology and therapeutic efficacy: B. N. Singh et al., Drugs 29, 531-569 (1985); G. DeBono et al., Am. Heart J. 109, 1211-1223 (1985). Comprehensive description: R. T. Foster, R. A. Carr, Anal. Profiles Drug Subs. 19, 1-26 (1990).
Properties: Crystals, mp 119-123°.
Melting point: mp 119-123°
 
Derivative Type: Hydrochloride
CAS Registry Number: 34381-68-5
Manufacturers' Codes: M & B 17803A; IL-17803A
Trademarks: Acecor (SPA); Acetanol (RPR); Neptal (Procter & Gamble); Prent (Bayer); Sectral (RPR)
Molecular Formula: C18H28N2O4.HCl
Molecular Weight: 372.89
Percent Composition: C 57.98%, H 7.84%, N 7.51%, O 17.16%, Cl 9.51%
Properties: Crystals from anhydr methanol-anhydr diethyl ether, mp 141-143°. Freely sol in water. Soly at room temperature (mg/ml): water 200; ethanol 70.
Melting point: mp 141-143°
 
Therap-Cat: Antihypertensive; antianginal; antiarrhythmic (class II).
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.