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CAS No 389-08-2 , 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid Search by region : Japan

  • Name: 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
  • Synonyms: Nalitucsan; Uronidix; Nalidixate; Nalidixan; Nevigramon; Unaserus; Innoxalon;1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;Nalidixin; Sicmylon;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 225-231 ºC
  • Density: 1.331 g/cm3
  • Water Solubility: 0.1 G/L (23 ºC)
  • Safety Statements: R40;R42/43;R63
  • Hazard Symbols: Xn: Harmful;
  • HS Code: 29339190
  • EINECS: 206-864-7
  • Molecular Weight: 232.23528
  • InchiKey: MHWLWQUZZRMNGJ-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H12N2O3/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14/h4-
    6H,3H2,1-2H3,(H,16,17)
  • Risk Statements: S22;S24;S36/37;S45
  • Molecular Formula: C12H12N2O3
  • Molecular Structure:CAS No:389-08-2 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid

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389-08-2 Nalidixic acid

  • Japan Nacalai Tesque, Inc. [Manufacturers]
  • Tel: 81 75 251 1723 81-75-251-1730
  • Fax: 81-75-251-1763
  • Address: Nijo Karasuma, Nakagyo-ku Kyoto 604-0855 Japan Nakagyo-ku,KyotoJapan
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References of 1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Title: Nalidixic Acid
CAS Registry Number: 389-08-2
CAS Name: 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid
Synonyms: 3-carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one; 1-ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid
Manufacturers' Codes: Win-18320
Trademarks: Betaxina (Terap. M. R.); Eucistin (San Carlo); Innoxalon (Sanko); Nalidicron (Toyo Shinyaku); Nalitucsan (Hishiyama); Narigix (Taiyo); NegGram (Sanofi Winthrop); Negram (Sanofi Winthrop); Nevigramon (Chinoin); Nicelate (Toyo Jozo); Nogram (Sanofi Winthrop); Poleon (Sumitomo); Specifin (Bergamon); Uriben (Rosemont); Uriclar (Crosara); Uralgin (Ceccarelli); Urodixin (Italchimici); Uroman (Toho Kogyo); Uroneg (Ibirn); Uropan (Tiber); Wintomylon (Daiichi)
Molecular Formula: C12H12N2O3
Molecular Weight: 232.24
Percent Composition: C 62.06%, H 5.21%, N 12.06%, O 20.67%
Literature References: Prepn: G. Y. Lesher et al., J. Med. Pharm. Chem. 5, 1063 (1962); G. Y. Lesher, M. D. Gruett, BE 612258; eidem, US 3590036 (1962, 1971 both to Sterling Drug). Mechanism of action studies: G. J. Bourguignon et al., Antimicrob. Agents Chemother. 4, 479 (1973); W. A. Goss, T. M. Cook, Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 174-196; A. M. Pedrini, ibid. vol. 5 (pt. 1), F. E. Hahn, Ed. (1979) pp 154-175; H. T. Wright et al., Science 213, 455 (1981). Comprehensive description: P. E. Grubb, Anal. Profiles Drug Subs. 8, 371-397 (1979).
Properties: Pale buff, crystalline powder, mp 229-230°. Soly at 23° (mg/ml): chloroform 35; toluene 1.6; methanol 1.3; ethanol 0.9; water 0.1; ether 0.1. LD50 in mice (mg/kg): 3300 orally; 500 s.c.; 176 i.v. (Lesher, 1962).
Melting point: mp 229-230°
Toxicity data: LD50 in mice (mg/kg): 3300 orally; 500 s.c.; 176 i.v. (Lesher, 1962)
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.