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CAS No 437-38-7 , N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide

  • Name: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
  • Synonyms: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide; Durogesic; Phentanyl; Fentanylum; Fentanil; Fentanest;Duragesic; Fentanila; Fentanylum [INN-Latin]; Sentonil;
  • CAS Registry Number:
  • Transport: 1544
  • Flash Point: 185.8°C
  • Boiling Point: 466.2°Cat760mmHg
  • Density: 1.087g/cm3
  • Safety Statements: Poison by intraperitoneal routes. Human systemic effects by intravenous route: somnolence, respiratory depression. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 185.8°C
  • EINECS: 207-113-6
  • Molecular Weight: 336.47052
  • InchiKey: PJMPHNIQZUBGLI-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H28N2O/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)
    16-13-19-9-5-3-6-10-19/h3-12,21H,2,13-18H2,1H3
  • Molecular Formula: C22H28N2O
  • Molecular Structure:CAS No:437-38-7 N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
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437-38-7 FENTANYL

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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437-38-7 Propanamide,N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-

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437-38-7 B-Hydroxyethyl theophylline

  • B-Hydroxyethyl theophylline
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,China
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437-38-7 Etofylline

  • Etofylline, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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437-38-7 Fentanyl

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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437-38-7 Propanamide,N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]-

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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437-38-7 Etofylline

  • Etofylline, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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437-38-7 Fentanyl

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437-38-7 Etofylline, 99%

  • Etofylline, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,China
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437-38-7 Fentanyl

  • Fentanyl, 99%
  • China Tianjin Pharmacn Science Co., Ltd. [Manufacturer]
  • Tel: 86-22-23359620/ 86-13612042162 (mobile)
  • Fax: 86-22-23359620
  • Address: 1006 Sinochem Building, 707 Lianmeng RD, Shijiazhuang 050061, Hebei, China ,China
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References of N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Title: Fentanyl
CAS Registry Number: 437-38-7
CAS Name: N-Phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamide
Synonyms: N-(1-phenethyl-4-piperidyl)propionanilide; N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide; phentanyl
Manufacturers' Codes: R-4263
Trademarks: Duragesic (J & J); Durogesic (J & J)
Molecular Formula: C22H28N2O
Molecular Weight: 336.47
Percent Composition: C 78.53%, H 8.39%, N 8.33%, O 4.76%
Literature References: Prepn: P. A. J. Janssen, FR 1344366; idem, US 3164600 (1963, 1965 both to Janssen). Pharmacology: J. F. Gardocki, J. Yelnosky, Toxicol. Appl. Pharmacol. 6, 48 (1964); R. Hess et al., J. Pharmacol. Exp. Ther. 179, 474 (1971). Effects on cerebral circulation and metabolism in rats: C. Carlsson et al., Anesthesiology 57, 375 (1982). Clinical studies: E. A. Welchew, J. A. Thornton, Anaesthesia 37, 309 (1982); M. J. Stephens et al., Med. J. Aust. 1, 419 (1982). Review of clinical experience with transdermal formulation: R. B. R. Muijsers, A. J. Wagstaff, Drugs 61, 2289-2307 (2001).
Properties: Crystals, mp 83-84°. Partition coefficient (n-octanol/water): 860. pKa 8.4.
Melting point: mp 83-84°
pKa: pKa 8.4
Log P: Partition coefficient (n-octanol/water): 860
 
Derivative Type: Citrate
CAS Registry Number: 990-73-8
Trademarks: Actiq (Cephalon); Fentanest (Pharmacia); Leptanal (Janssen-Cilag); Sublimaze (Janssen)
Molecular Formula: C22H28N2O.C6H8O7
Molecular Weight: 528.59
Percent Composition: C 63.62%, H 6.86%, N 5.30%, O 24.21%
Properties: Crystalline powder, mp 149-151°. Bitter taste. One gram dissolves in about 40 ml water. Sol in methanol; sparingly sol in chloroform. LD50 in mice (mg/kg): 11.2 i.v.; 62 s.c. (Gardocki, Yelnosky).
Melting point: mp 149-151°
Toxicity data: LD50 in mice (mg/kg): 11.2 i.v.; 62 s.c. (Gardocki, Yelnosky)
 
NOTE: This is a controlled substance (opiate): 21 CFR, 1308.12.
Therap-Cat: Analgesic (narcotic).
Therap-Cat-Vet: Analgesic; tranquilizer.
Keywords: Analgesic (Narcotic).