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CAS No 443-48-1 , 2-(2-methyl-5-nitroimidazol-1-yl)ethanol

  • Name: 2-(2-methyl-5-nitroimidazol-1-yl)ethanol
  • Synonyms: 2-(2-methyl-5-nitroimidazol-1-yl)ethanol; Metronidazol; Meronidal; Danizol; Gineflavir; Metronidaz; Trivazol; Trichazol; Trichopol;Flagyl;
  • CAS Registry Number:
  • Melting Point: 159-163 ºC
  • Density: 1.45 g/cm3
  • Refractive index: 1.612
  • Water Solubility: <0.1 G/100 ML AT 20 ºC
  • Safety Statements: R40
  • Hazard Symbols: Xn: Harmful;
  • HS Code: 29332990
  • EINECS: 207-136-1
  • Molecular Weight: 171.15396
  • InchiKey: VAOCPAMSLUNLGC-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
  • Risk Statements: S36/37;S45
  • Molecular Formula: C6H9N3O3
  • Molecular Structure:CAS No:443-48-1 2-(2-methyl-5-nitroimidazol-1-yl)ethanol

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443-48-1 METRONIDAZOLE

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443-48-1 METRONIDAZOLE CP2005BP

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443-48-1 Metronidazole

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443-48-1 Metronidazole

  • Metronidazole CAS No.: 443-48-1 MF: C6H9N3O3 MW: 171.15 Specification: BP2008 Description: White to pale-yellow crystalline powder with a slight odor. Bitter and saline taste. Usage: It is used as antifungals. Metronidazole darkens on exposure to lig...
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References of 2-(2-methyl-5-nitroimidazol-1-yl)ethanol
Title: Metronidazole
CAS Registry Number: 443-48-1
CAS Name: 2-Methyl-5-nitroimidazole-1-ethanol
Synonyms: 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(b-ethylol)-2-methyl-5-nitro-3-azapyrrole
Manufacturers' Codes: Bayer 5630; RP-8823
Trademarks: Acea Gel (Ferndale); Anabact (Cambridge Healthcare); Arilin (Wolff); Clont (Infectopharm); Deflamon (SPA); Elyzol (Dumex); Flagyl (Searle); Fossyol (Merckle); Klion (Gedeon Richter); MetroGel (Galderma); Metrolag (Lagap); Metrolyl (Sandoz); Metrosa (Linderma); Metrotop (Medlock); Orvagil (Galenika); Rathimed (Pfleger); Rosaced (Fabre); Rozacrème (Biorga); Rozagel (Biorga); Rozex (Galderma); Trichocide (Mitsubishi); Vagilen (Alfa); Vagimid (Apogepha); Zadstat (Wyeth); Zidoval (3M Pharma)
Molecular Formula: C6H9N3O3
Molecular Weight: 171.15
Percent Composition: C 42.11%, H 5.30%, N 24.55%, O 28.04%
Literature References: Prepn: Jacob et al., US 2944061 (1960 to Rh?ne-Poulenc); Cossar et al., Arzneim.-Forsch. 16, 23 (1966). Activity studies: Bock, ibid. 11, 587 (1961). Metabolism: Ings et al., Biochem. Pharmacol. 15, 515 (1966). Comprehensive description: L. L. Wearley, G. D. Anthony, Anal. Profiles Drug Subs. 5, 327-344 (1976). Review of activity, pharmacokinetics and use in anaerobic infection: R. N. Brogden et al., Drugs 16, 387-417 (1978); in rosacea: L. K. Schmadel, G. K. McEvoy, Clin. Pharm. 9, 94-101 (1990). Review: W. D. Hager, R. P. Rapp, Obstet. Gynecol. Clin. North Am. 19, 497-510 (1992).
Properties: Cream-colored crystals, mp 158-160°. Soly at 20° (g/100 ml): water 1.0; ethanol 0.5; ether <0.05; chloroform <0.05. Sparingly sol in DMF. Sol in dil acids. pH of satd aq soln: 5.8.
Melting point: mp 158-160°
 
Derivative Type: Hydrochloride
CAS Registry Number: 69198-10-3
Manufacturers' Codes: SC-326421
Molecular Formula: C6H9N3O3.HCl
Molecular Weight: 207.61
Percent Composition: C 34.71%, H 4.85%, N 20.24%, O 23.12%, Cl 17.08%
 
CAUTION: Metronidazole is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-173.
Therap-Cat: Antiprotozoal (Trichomonas); antibacterial; in treatment of rosacea.
Therap-Cat-Vet: Antiprotozoal (Trichomonas); antiamebic; antibacterial.
Keywords: Antibacterial (Synthetic); Antiprotozoal (Trichomonas).