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CAS No 4759-48-2 , Isotretinoin

  • Name: Isotretinoin
  • Synonyms: 13-cis-Retinoic acid; 13-cis-vitamin a acid; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid;Isotretinoin;13-cis-retinoic acid; 13-cis-Vitamin A acid;
  • CAS Registry Number:
  • Melting Point: 174-177 ºC
  • Density: 1.011 g/cm3
  • Safety Statements: R36/37/38;R61
  • Hazard Symbols: T: Toxic;
  • EINECS: 225-296-0
  • Molecular Weight: 300.44
  • InChI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
  • Risk Statements: S26;S37/39;S45;S53
  • Molecular Formula: C20H28O2
  • Molecular Structure:CAS No:4759-48-2 Isotretinoin

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References of Isotretinoin
Title: Isotretinoin
CAS Registry Number: 4759-48-2
CAS Name: 13-cis-Retinoic acid
Synonyms: 2-cis-vitamin A acid; neovitamin A acid
Manufacturers' Codes: Ro-4-3780
Trademarks: Accutane (Roche); Isotrex (Stiefel); Oratane (Douglas); Roaccutane (Roche)
Molecular Formula: C20H28O2
Molecular Weight: 300.44
Percent Composition: C 79.95%, H 9.39%, O 10.65%
Literature References: Naturally occurring metabolite of vitamin A, q.v.; inhibits sebum production. Prepn: C. D. Robeson et al., J. Am. Chem. Soc. 77, 4111 (1955). Stereoselective process: R. Lucci, EP 111325; idem, US 4556518 (1984, 1985 both to Hoffmann-La Roche). Toxicology and teratogenicity study: J. J. Kamm, J. Am. Acad. Dermatol. 6, 652 (1982). Identification as endogenous metabolite of all-trans-retinoic acid: M. E. Cullum, M. H. Zile, J. Biol. Chem. 260, 10590 (1985). HPLC determn in serum: G. Tang, R. M. Russell, J. Lipid Res. 31, 175 (1990). Review of pharmacology and clinical efficacy in acne: A. R. Shalita et al., Cutis 42, Suppl. 6A, 1-19 (1988). Symposium on clinical experience: Dermatology 195, Suppl. 1, 1-37 (1997).
Properties: Reddish-orange plates from isopropyl alcohol, mp 174-175°. uv max: 354 nm (e 39800). LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm).
Melting point: mp 174-175°
Absorption maximum: uv max: 354 nm (e 39800)
Toxicity data: LD50 (20 day) in mice, rats (mg/kg): 904, 901 i.p.; 3389, >4000 orally (Kamm)
Therap-Cat: Antiacne.
Keywords: Antiacne.