Title: Berbamine
CAS Registry Number: 478-61-5
CAS Name: (4a
S,16a
R)-3,4,4a,5,16a,17,18,19-Octahydro-21,22,26-trimethoxy-4,17-dimethyl-16
H-1,24:6,9-dietheno-11,15-metheno-2
H-pyrido[2¢,3¢:17,18][1,11]dioxacycloeicosino[2,3,4-
ij]isoquinolin-12-ol
Synonyms: 6,6¢,7-trimethoxy-2,2¢-dimethylberbaman-12-ol; berbenine
Molecular Formula: C37H40N2O6
Molecular Weight: 608.72
Percent Composition: C 73.00%, H 6.62%, N 4.60%, O 15.77%
Literature References: Alkaloid found in various members of Berberis family. Used as a traditional medicine in China as antipyretic, antidiarrheoa and as a tonic. Identification in
Berberis vulgaris: C. Rüdel,
Arch. Pharm. 229, 631 (1895); isoln from
Atherosperma moschatum Labill.,
Monimiaceae: I. R. C. Bick
et al., Aust. J. Chem. 9, 111 (1956). Structure: F. von Bruchhausen
et al., Ann. 507, 144 (1933); configuration: Y. Inubishi,
J. Pharm. Soc. Jpn. 72, 220 (1952),
C.A. 47, 6429e (1953). Immunopharmacology and toxicology: C. W. Wong
et al., Int. J. Immunopharmacol. 13, 579 (1991). Brief review: C.-X. Liu
et al., Phytother. Res. 5, 228-230 (1991).
Properties: Colorless plates from aq ethanol as the monohydrate, sinters 147°. pKa (20°): 7.33 in aq methanol. [a]D20 +114.6° (c = 1.0 in chloroform). uv max (ethanol): 282 nm (log e 3.89; E 1cm1% 126).
pKa: pKa (20°): 7.33 in aq methanol
Optical Rotation: [a]D20 +114.6° (c = 1.0 in chloroform)
Absorption maximum: uv max (ethanol): 282 nm (log e 3.89; E 1cm1% 126)